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Association between endometriosis and hyperprolactinemia in infertile women

BACKGROUND: The association of endometriosis with hyperprolactinemia is controversial. OBJECTIVE: The present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women. MATERIALS AND METHODS: 256 infertile women who underwent diagnosti...

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Autores principales: Esmaeilzadeh, Seddigheh, Mirabi, Parvaneh, Basirat, Zahra, Zeinalzadeh, Mahtab, Khafri, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426155/
https://www.ncbi.nlm.nih.gov/pubmed/26000006
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author Esmaeilzadeh, Seddigheh
Mirabi, Parvaneh
Basirat, Zahra
Zeinalzadeh, Mahtab
Khafri, Soraya
author_facet Esmaeilzadeh, Seddigheh
Mirabi, Parvaneh
Basirat, Zahra
Zeinalzadeh, Mahtab
Khafri, Soraya
author_sort Esmaeilzadeh, Seddigheh
collection PubMed
description BACKGROUND: The association of endometriosis with hyperprolactinemia is controversial. OBJECTIVE: The present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women. MATERIALS AND METHODS: 256 infertile women who underwent diagnostic laparoscopy for the evaluation of infertility, referred to Fatemezahra Infertility and Reproductive Health Research Center were included in a cross-sectional study. The presence of endometriosis was evaluated. To investigate the association of endometriosis with hyperprolactinemia, the patients whose infertility was not caused by endometriosis were included as control group. Serum prolactin (PRL) level was measured in both groups. The comparison of basal serum PRL levels between the two groups was performed, using independent t-test. One way ANOVA was used to determine PRL association with endometriosis stages. RESULTS: The frequency of endometriosis was found to be 29%. PRL levels were significantly higher in endometriosis group compared to control group (23.02±1.25 vs. 17.22±1.22 respectively, p=0.004). Statistically significant associations were found between staging of endometriosis and prolactin levels (p=0.01). CONCLUSION: Hyperprolactinemia may be associated with endometriosis and its progression.
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spelling pubmed-44261552015-05-21 Association between endometriosis and hyperprolactinemia in infertile women Esmaeilzadeh, Seddigheh Mirabi, Parvaneh Basirat, Zahra Zeinalzadeh, Mahtab Khafri, Soraya Iran J Reprod Med Original Article BACKGROUND: The association of endometriosis with hyperprolactinemia is controversial. OBJECTIVE: The present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women. MATERIALS AND METHODS: 256 infertile women who underwent diagnostic laparoscopy for the evaluation of infertility, referred to Fatemezahra Infertility and Reproductive Health Research Center were included in a cross-sectional study. The presence of endometriosis was evaluated. To investigate the association of endometriosis with hyperprolactinemia, the patients whose infertility was not caused by endometriosis were included as control group. Serum prolactin (PRL) level was measured in both groups. The comparison of basal serum PRL levels between the two groups was performed, using independent t-test. One way ANOVA was used to determine PRL association with endometriosis stages. RESULTS: The frequency of endometriosis was found to be 29%. PRL levels were significantly higher in endometriosis group compared to control group (23.02±1.25 vs. 17.22±1.22 respectively, p=0.004). Statistically significant associations were found between staging of endometriosis and prolactin levels (p=0.01). CONCLUSION: Hyperprolactinemia may be associated with endometriosis and its progression. Research and Clinical Center for Infertility 2015-03 /pmc/articles/PMC4426155/ /pubmed/26000006 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Esmaeilzadeh, Seddigheh
Mirabi, Parvaneh
Basirat, Zahra
Zeinalzadeh, Mahtab
Khafri, Soraya
Association between endometriosis and hyperprolactinemia in infertile women
title Association between endometriosis and hyperprolactinemia in infertile women
title_full Association between endometriosis and hyperprolactinemia in infertile women
title_fullStr Association between endometriosis and hyperprolactinemia in infertile women
title_full_unstemmed Association between endometriosis and hyperprolactinemia in infertile women
title_short Association between endometriosis and hyperprolactinemia in infertile women
title_sort association between endometriosis and hyperprolactinemia in infertile women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426155/
https://www.ncbi.nlm.nih.gov/pubmed/26000006
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