Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

[Image: see text] Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2-a]pyridi...

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Detalles Bibliográficos
Autores principales: Moraski, Garrett C., Miller, Patricia A., Bailey, Mai Ann, Ollinger, Juliane, Parish, Tanya, Boshoff, Helena I., Cho, Sanghyun, Anderson, Jeffery R., Mulugeta, Surafel, Franzblau, Scott G., Miller, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426345/
https://www.ncbi.nlm.nih.gov/pubmed/25984566
http://dx.doi.org/10.1021/id500008t

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