A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein

[Image: see text] An ultrahigh-throughput screen was performed to identify novel small molecule inhibitors of influenza virus replication. The screen employed a recombinant influenza A/WSN/33 virus expressing Renilla luciferase and yielded a hit rate of 0.5%, of which the vast majority showed little...

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Detalles Bibliográficos
Autores principales: White, Kris M., De Jesus, Paul, Chen, Zhong, Abreu, Pablo, Barile, Elisa, Mak, Puiying A., Anderson, Paul, Nguyen, Quy T., Inoue, Atsushi, Stertz, Silke, Koenig, Renate, Pellecchia, Maurizio, Palese, Peter, Kuhen, Kelli, García-Sastre, Adolfo, Chanda, Sumit K., Shaw, Megan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426349/
https://www.ncbi.nlm.nih.gov/pubmed/25984567
http://dx.doi.org/10.1021/id500022h

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