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3D Printing with Nucleic Acid Adhesives

[Image: see text] By relying on specific DNA:DNA interactions as a “smart glue”, we have assembled microparticles into a colloidal gel that can hold its shape. This gel can be extruded with a 3D printer to generate centimeter size objects. We show four aspects of this material: (1) The colloidal gel...

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Autores principales: Allen, Peter B., Khaing, Zin, Schmidt, Christine E., Ellington, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426351/
https://www.ncbi.nlm.nih.gov/pubmed/25984570
http://dx.doi.org/10.1021/ab500026f
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author Allen, Peter B.
Khaing, Zin
Schmidt, Christine E.
Ellington, Andrew D.
author_facet Allen, Peter B.
Khaing, Zin
Schmidt, Christine E.
Ellington, Andrew D.
author_sort Allen, Peter B.
collection PubMed
description [Image: see text] By relying on specific DNA:DNA interactions as a “smart glue”, we have assembled microparticles into a colloidal gel that can hold its shape. This gel can be extruded with a 3D printer to generate centimeter size objects. We show four aspects of this material: (1) The colloidal gel material holds its shape after extrusion. (2) The connectivity among the particles is controlled by the binding behavior between the surface DNA and this mediates some control over the microscale structure. (3) The use of DNA-coated microparticles dramatically reduces the cost of DNA-mediated assembly relative to conventional DNA nanotechnologies and makes this material accessible for macroscale applications. (4) This material can be assembled under biofriendly conditions and can host growing cells within its matrix. The DNA-based control over organization should provide a new means of engineering bioprinted tissues.
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spelling pubmed-44263512015-12-17 3D Printing with Nucleic Acid Adhesives Allen, Peter B. Khaing, Zin Schmidt, Christine E. Ellington, Andrew D. ACS Biomater Sci Eng [Image: see text] By relying on specific DNA:DNA interactions as a “smart glue”, we have assembled microparticles into a colloidal gel that can hold its shape. This gel can be extruded with a 3D printer to generate centimeter size objects. We show four aspects of this material: (1) The colloidal gel material holds its shape after extrusion. (2) The connectivity among the particles is controlled by the binding behavior between the surface DNA and this mediates some control over the microscale structure. (3) The use of DNA-coated microparticles dramatically reduces the cost of DNA-mediated assembly relative to conventional DNA nanotechnologies and makes this material accessible for macroscale applications. (4) This material can be assembled under biofriendly conditions and can host growing cells within its matrix. The DNA-based control over organization should provide a new means of engineering bioprinted tissues. American Chemical Society 2014-12-17 2015-01-12 /pmc/articles/PMC4426351/ /pubmed/25984570 http://dx.doi.org/10.1021/ab500026f Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Allen, Peter B.
Khaing, Zin
Schmidt, Christine E.
Ellington, Andrew D.
3D Printing with Nucleic Acid Adhesives
title 3D Printing with Nucleic Acid Adhesives
title_full 3D Printing with Nucleic Acid Adhesives
title_fullStr 3D Printing with Nucleic Acid Adhesives
title_full_unstemmed 3D Printing with Nucleic Acid Adhesives
title_short 3D Printing with Nucleic Acid Adhesives
title_sort 3d printing with nucleic acid adhesives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426351/
https://www.ncbi.nlm.nih.gov/pubmed/25984570
http://dx.doi.org/10.1021/ab500026f
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