Mapping Bias Overestimates Reference Allele Frequencies at the HLA Genes in the 1000 Genomes Project Phase I Data

Next-generation sequencing (NGS) technologies have become the standard for data generation in studies of population genomics, as the 1000 Genomes Project (1000G). However, these techniques are known to be problematic when applied to highly polymorphic genomic regions, such as the human leukocyte ant...

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Detalles Bibliográficos
Autores principales: Brandt, Débora Y. C., Aguiar, Vitor R. C., Bitarello, Bárbara D., Nunes, Kelly, Goudet, Jérôme, Meyer, Diogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426377/
https://www.ncbi.nlm.nih.gov/pubmed/25787242
http://dx.doi.org/10.1534/g3.114.015784

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