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The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report
CONTEXT: Somato-sensitive innervation of bowels are maintained by lower segments of spinal cord and the blood supply of the lower spinal cord is heavily dependent on Adamkiewicz artery. Although bowel problems are sometimes seen in subarachnoid hemorrhage neither Adamkiewicz artery spasm nor spinal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426525/ https://www.ncbi.nlm.nih.gov/pubmed/25972712 http://dx.doi.org/10.4103/0974-8237.156056 |
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author | Ozturk, Cengiz Kanat, Ayhan Aydin, Mehmet Dumlu Yolas, Coskun Kabalar, Mehmet Esref Gundogdu, Betul Duman, Aslihan Kanat, Ilyas Ferit Gundogdu, Cemal |
author_facet | Ozturk, Cengiz Kanat, Ayhan Aydin, Mehmet Dumlu Yolas, Coskun Kabalar, Mehmet Esref Gundogdu, Betul Duman, Aslihan Kanat, Ilyas Ferit Gundogdu, Cemal |
author_sort | Ozturk, Cengiz |
collection | PubMed |
description | CONTEXT: Somato-sensitive innervation of bowels are maintained by lower segments of spinal cord and the blood supply of the lower spinal cord is heavily dependent on Adamkiewicz artery. Although bowel problems are sometimes seen in subarachnoid hemorrhage neither Adamkiewicz artery spasm nor spinal cord ischemia has not been elucidated as a cause of bowel dilatation so far. AIMS: The goal of this study was to study the effects Adamkiewicz artery (AKA) vasospasm in lumbar subarachnoid hemorrhage (SAH) on bowel dilatation severity. SETTINGS AND DESIGN: An experimental rabbit study. MATERIALS AND METHODS: The study was conducted on 25 rabbits, which were randomly divided into three groups: Spinal SAH (N = 13), serum saline (SS) (SS; N = 7) and control (N = 5) groups. Experimental spinal SAH was performed. After 21 days, volume values of descending parts of large bowels and degenerated neuron density of L5DRG were analyzed. STATISTICAL ANALYSIS USED: Statistical analysis was performed using the PASW Statistics 18.0 for Windows (SPSS Inc., Chicago, Illinois). Two-tailed t-test and Mann-Whitney U-tests were used. The statistical significance was set at P < 0.05. RESULTS: The mean volume of imaginary descending colons was estimated as 93 ± 12 cm(3) in the control group and 121 ± 26 cm(3) in the SS group and 176 ± 49 cm(3) in SAH group. Volume augmentations of the descending colons and degenerated neuron density L5DRG were significantly different between the SAH and other two groups (P < 0.05). CONCLUSION: An inverse relationship between the living neuronal density of the L5DRG and the volume of imaginary descending colon values was occurred. Our findings will aid in the planning of future experimental studies and determining the clinical relevance on such studies. |
format | Online Article Text |
id | pubmed-4426525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44265252015-05-13 The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report Ozturk, Cengiz Kanat, Ayhan Aydin, Mehmet Dumlu Yolas, Coskun Kabalar, Mehmet Esref Gundogdu, Betul Duman, Aslihan Kanat, Ilyas Ferit Gundogdu, Cemal J Craniovertebr Junction Spine Original Article CONTEXT: Somato-sensitive innervation of bowels are maintained by lower segments of spinal cord and the blood supply of the lower spinal cord is heavily dependent on Adamkiewicz artery. Although bowel problems are sometimes seen in subarachnoid hemorrhage neither Adamkiewicz artery spasm nor spinal cord ischemia has not been elucidated as a cause of bowel dilatation so far. AIMS: The goal of this study was to study the effects Adamkiewicz artery (AKA) vasospasm in lumbar subarachnoid hemorrhage (SAH) on bowel dilatation severity. SETTINGS AND DESIGN: An experimental rabbit study. MATERIALS AND METHODS: The study was conducted on 25 rabbits, which were randomly divided into three groups: Spinal SAH (N = 13), serum saline (SS) (SS; N = 7) and control (N = 5) groups. Experimental spinal SAH was performed. After 21 days, volume values of descending parts of large bowels and degenerated neuron density of L5DRG were analyzed. STATISTICAL ANALYSIS USED: Statistical analysis was performed using the PASW Statistics 18.0 for Windows (SPSS Inc., Chicago, Illinois). Two-tailed t-test and Mann-Whitney U-tests were used. The statistical significance was set at P < 0.05. RESULTS: The mean volume of imaginary descending colons was estimated as 93 ± 12 cm(3) in the control group and 121 ± 26 cm(3) in the SS group and 176 ± 49 cm(3) in SAH group. Volume augmentations of the descending colons and degenerated neuron density L5DRG were significantly different between the SAH and other two groups (P < 0.05). CONCLUSION: An inverse relationship between the living neuronal density of the L5DRG and the volume of imaginary descending colon values was occurred. Our findings will aid in the planning of future experimental studies and determining the clinical relevance on such studies. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4426525/ /pubmed/25972712 http://dx.doi.org/10.4103/0974-8237.156056 Text en Copyright: © Journal of Craniovertebral Junction and Spine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ozturk, Cengiz Kanat, Ayhan Aydin, Mehmet Dumlu Yolas, Coskun Kabalar, Mehmet Esref Gundogdu, Betul Duman, Aslihan Kanat, Ilyas Ferit Gundogdu, Cemal The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title | The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title_full | The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title_fullStr | The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title_full_unstemmed | The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title_short | The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report |
title_sort | impact of l5 dorsal root ganglion degeneration and adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: an experimental study; first report |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426525/ https://www.ncbi.nlm.nih.gov/pubmed/25972712 http://dx.doi.org/10.4103/0974-8237.156056 |
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