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Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam

A descriptive study on rickettsiosis was conducted at the largest referral hospital in Hanoi, Vietnam, to identify epidemiological and clinical characteristics of specific rickettsiosis. Between March 2001 and February 2003, we enrolled 579 patients with acute undifferentiated fever (AUF), excluding...

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Autores principales: Hamaguchi, Sugihiro, Cuong, Ngo Chi, Tra, Doan Thu, Doan, Yen Hai, Shimizu, Kenta, Tuan, Nguyen Quang, Yoshida, Lay-Myint, Mai, Le Quynh, Duc-Anh, Dang, Ando, Shuji, Arikawa, Jiro, Parry, Christopher M., Ariyoshi, Koya, Thuy, Pham Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426587/
https://www.ncbi.nlm.nih.gov/pubmed/25778504
http://dx.doi.org/10.4269/ajtmh.14-0806
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author Hamaguchi, Sugihiro
Cuong, Ngo Chi
Tra, Doan Thu
Doan, Yen Hai
Shimizu, Kenta
Tuan, Nguyen Quang
Yoshida, Lay-Myint
Mai, Le Quynh
Duc-Anh, Dang
Ando, Shuji
Arikawa, Jiro
Parry, Christopher M.
Ariyoshi, Koya
Thuy, Pham Thanh
author_facet Hamaguchi, Sugihiro
Cuong, Ngo Chi
Tra, Doan Thu
Doan, Yen Hai
Shimizu, Kenta
Tuan, Nguyen Quang
Yoshida, Lay-Myint
Mai, Le Quynh
Duc-Anh, Dang
Ando, Shuji
Arikawa, Jiro
Parry, Christopher M.
Ariyoshi, Koya
Thuy, Pham Thanh
author_sort Hamaguchi, Sugihiro
collection PubMed
description A descriptive study on rickettsiosis was conducted at the largest referral hospital in Hanoi, Vietnam, to identify epidemiological and clinical characteristics of specific rickettsiosis. Between March 2001 and February 2003, we enrolled 579 patients with acute undifferentiated fever (AUF), excluding patients with malaria, dengue fever, and typhoid fever, and serologically tested for Orientia tsutsugamushi and Rickettsia typhi. Of the patients, 237 (40.9%) and 193 (33.3%) had scrub and murine typhus, respectively, and 149 (25.7%) had neither of them (non–scrub and murine typhus [non-ST/MT]). The proportion of murine typhus was highest among patients living in Hanoi whereas that of scrub typhus was highest in national or regional border areas. The presence of an eschar, dyspnea, hypotension, and lymphadenopathy was significantly associated with a diagnosis of scrub typhus (OR = 46.56, 10.90, 9.01, and 7.92, respectively). Patients with murine typhus were less likely to have these findings but more likely to have myalgia, rash, and relative bradycardia (OR = 1.60, 1.56, and 1.45, respectively). Scrub typhus and murine typhus were shown to be common causes of AUF in northern Vietnam although the occurrence of spotted fever group rickettsiae was not determined. Clinical and epidemiological information may help local clinicians make clinical diagnosis of specific rickettsioses in a resource-limited setting.
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spelling pubmed-44265872015-05-12 Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam Hamaguchi, Sugihiro Cuong, Ngo Chi Tra, Doan Thu Doan, Yen Hai Shimizu, Kenta Tuan, Nguyen Quang Yoshida, Lay-Myint Mai, Le Quynh Duc-Anh, Dang Ando, Shuji Arikawa, Jiro Parry, Christopher M. Ariyoshi, Koya Thuy, Pham Thanh Am J Trop Med Hyg Articles A descriptive study on rickettsiosis was conducted at the largest referral hospital in Hanoi, Vietnam, to identify epidemiological and clinical characteristics of specific rickettsiosis. Between March 2001 and February 2003, we enrolled 579 patients with acute undifferentiated fever (AUF), excluding patients with malaria, dengue fever, and typhoid fever, and serologically tested for Orientia tsutsugamushi and Rickettsia typhi. Of the patients, 237 (40.9%) and 193 (33.3%) had scrub and murine typhus, respectively, and 149 (25.7%) had neither of them (non–scrub and murine typhus [non-ST/MT]). The proportion of murine typhus was highest among patients living in Hanoi whereas that of scrub typhus was highest in national or regional border areas. The presence of an eschar, dyspnea, hypotension, and lymphadenopathy was significantly associated with a diagnosis of scrub typhus (OR = 46.56, 10.90, 9.01, and 7.92, respectively). Patients with murine typhus were less likely to have these findings but more likely to have myalgia, rash, and relative bradycardia (OR = 1.60, 1.56, and 1.45, respectively). Scrub typhus and murine typhus were shown to be common causes of AUF in northern Vietnam although the occurrence of spotted fever group rickettsiae was not determined. Clinical and epidemiological information may help local clinicians make clinical diagnosis of specific rickettsioses in a resource-limited setting. The American Society of Tropical Medicine and Hygiene 2015-05-06 /pmc/articles/PMC4426587/ /pubmed/25778504 http://dx.doi.org/10.4269/ajtmh.14-0806 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Hamaguchi, Sugihiro
Cuong, Ngo Chi
Tra, Doan Thu
Doan, Yen Hai
Shimizu, Kenta
Tuan, Nguyen Quang
Yoshida, Lay-Myint
Mai, Le Quynh
Duc-Anh, Dang
Ando, Shuji
Arikawa, Jiro
Parry, Christopher M.
Ariyoshi, Koya
Thuy, Pham Thanh
Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title_full Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title_fullStr Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title_full_unstemmed Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title_short Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam
title_sort clinical and epidemiological characteristics of scrub typhus and murine typhus among hospitalized patients with acute undifferentiated fever in northern vietnam
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426587/
https://www.ncbi.nlm.nih.gov/pubmed/25778504
http://dx.doi.org/10.4269/ajtmh.14-0806
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