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Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase

Streptosporangium sibiricum SibL catalyzes the methyl transfer from S-adenosylmethionine (SAM) to 3-hydroxykynurenine (3-HK) to produce S-adenosylhomocysteine (SAH) and 3-hydroxy-4-methyl-kynurenine for sibiromycin biosynthesis. Here, we present the crystal structures of apo-form Ss-SibL, Ss-SibL/SA...

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Detalles Bibliográficos
Autores principales:	Chen, Sheng-Chia, Huang, Chi-Hung, Lai, Shu-Jung, Liu, Jai-Shin, Fu, Pin-Kuei, Tseng, Shih-Ting, Yang, Chia Shin, Lai, Mei-Chin, Ko, Tzu-Ping, Chen, Yeh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426599/ https://www.ncbi.nlm.nih.gov/pubmed/25960001 http://dx.doi.org/10.1038/srep10100

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