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Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?

Invasive aspergillosis caused by Aspergillus species (Aspergillus fumigatus, A. flavus, and A. terreus) is life-threatening infections in immunocompromised patients. Understanding the innate and adaptive immune response particularly T-helper cells (T(H)-cells) against these Aspergillus species and h...

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Autores principales: Thakur, Raman, Anand, Rajesh, Tiwari, Shraddha, Singh, Agam P., Tiwary, Bhupendra N., Shankar, Jata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426709/
https://www.ncbi.nlm.nih.gov/pubmed/26029179
http://dx.doi.org/10.3389/fmicb.2015.00429
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author Thakur, Raman
Anand, Rajesh
Tiwari, Shraddha
Singh, Agam P.
Tiwary, Bhupendra N.
Shankar, Jata
author_facet Thakur, Raman
Anand, Rajesh
Tiwari, Shraddha
Singh, Agam P.
Tiwary, Bhupendra N.
Shankar, Jata
author_sort Thakur, Raman
collection PubMed
description Invasive aspergillosis caused by Aspergillus species (Aspergillus fumigatus, A. flavus, and A. terreus) is life-threatening infections in immunocompromised patients. Understanding the innate and adaptive immune response particularly T-helper cells (T(H)-cells) against these Aspergillus species and how the different sub-set of T(H)-cells are regulated by differentiating cytokines at primary target organ site like lung, kidney and brain is of great significance to human health. This review focuses on presentation of Aspergillus through Antigen presenting cells (APCs) to the naive CD4(+) T-cells in the host. The production of differentiating/effector cytokines that activate following T(H)-cells, e.g., T(H)1, T(H)2, T(H)9, and T(H)17 has been reported in association or alone in allergic or invasive aspergillosis. Chemokines (CXCL1, CXCL2, CCL1, and CCL20) and their receptors associated to these T(H)-cells have also been observed in invasive aspergillosis. Thus, further study of these T(H)-cells in invasive aspergillosis and other elements of adaptive immune response with Aspergillus species are required in order to have a better understanding of host response for safer and effective therapeutic outcome.
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spelling pubmed-44267092015-05-29 Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells? Thakur, Raman Anand, Rajesh Tiwari, Shraddha Singh, Agam P. Tiwary, Bhupendra N. Shankar, Jata Front Microbiol Microbiology Invasive aspergillosis caused by Aspergillus species (Aspergillus fumigatus, A. flavus, and A. terreus) is life-threatening infections in immunocompromised patients. Understanding the innate and adaptive immune response particularly T-helper cells (T(H)-cells) against these Aspergillus species and how the different sub-set of T(H)-cells are regulated by differentiating cytokines at primary target organ site like lung, kidney and brain is of great significance to human health. This review focuses on presentation of Aspergillus through Antigen presenting cells (APCs) to the naive CD4(+) T-cells in the host. The production of differentiating/effector cytokines that activate following T(H)-cells, e.g., T(H)1, T(H)2, T(H)9, and T(H)17 has been reported in association or alone in allergic or invasive aspergillosis. Chemokines (CXCL1, CXCL2, CCL1, and CCL20) and their receptors associated to these T(H)-cells have also been observed in invasive aspergillosis. Thus, further study of these T(H)-cells in invasive aspergillosis and other elements of adaptive immune response with Aspergillus species are required in order to have a better understanding of host response for safer and effective therapeutic outcome. Frontiers Media S.A. 2015-05-11 /pmc/articles/PMC4426709/ /pubmed/26029179 http://dx.doi.org/10.3389/fmicb.2015.00429 Text en Copyright © 2015 Thakur, Anand, Tiwari, Singh, Tiwary and Shankar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Thakur, Raman
Anand, Rajesh
Tiwari, Shraddha
Singh, Agam P.
Tiwary, Bhupendra N.
Shankar, Jata
Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title_full Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title_fullStr Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title_full_unstemmed Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title_short Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?
title_sort cytokines induce effector t-helper cells during invasive aspergillosis; what we have learned about t-helper cells?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426709/
https://www.ncbi.nlm.nih.gov/pubmed/26029179
http://dx.doi.org/10.3389/fmicb.2015.00429
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