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Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy
Using diffusion-tensor magnetic resonance imaging and fiber tractography the topographic organization of the human corpus callosum (CC) has been described to comprise five segments with fibers projecting into prefrontal (I), premotor and supplementary motor (II), primary motor (III), and primary sen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426710/ https://www.ncbi.nlm.nih.gov/pubmed/26029059 http://dx.doi.org/10.3389/fnana.2015.00057 |
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author | Hofer, Sabine Wang, Xiaoqing Roeloffs, Volkert Frahm, Jens |
author_facet | Hofer, Sabine Wang, Xiaoqing Roeloffs, Volkert Frahm, Jens |
author_sort | Hofer, Sabine |
collection | PubMed |
description | Using diffusion-tensor magnetic resonance imaging and fiber tractography the topographic organization of the human corpus callosum (CC) has been described to comprise five segments with fibers projecting into prefrontal (I), premotor and supplementary motor (II), primary motor (III), and primary sensory areas (IV), as well as into parietal, temporal, and occipital cortical areas (V). In order to more rapidly characterize the underlying anatomy of these segments, this study used a novel single-shot T1 mapping method to quantitatively determine T1 relaxation times in the human CC. A region-of-interest analysis revealed a tendency for the lowest T1 relaxation times in the genu and the highest T1 relaxation times in the somatomotor region of the CC. This observation separates regions dominated by myelinated fibers with large diameters (somatomotor area) from densely packed smaller axonal bundles (genu) with less myelin. The results indicate that characteristic T1 relaxation times in callosal profiles provide an additional means to monitor differences in fiber anatomy, fiber density, and gray matter in respective neocortical areas. In conclusion, rapid T1 mapping allows for a characterization of the axonal architecture in an individual CC in less than 10 s. The approach emerges as a valuable means for studying neocortical brain anatomy with possible implications for the diagnosis of neurodegenerative processes. |
format | Online Article Text |
id | pubmed-4426710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44267102015-05-29 Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy Hofer, Sabine Wang, Xiaoqing Roeloffs, Volkert Frahm, Jens Front Neuroanat Neuroanatomy Using diffusion-tensor magnetic resonance imaging and fiber tractography the topographic organization of the human corpus callosum (CC) has been described to comprise five segments with fibers projecting into prefrontal (I), premotor and supplementary motor (II), primary motor (III), and primary sensory areas (IV), as well as into parietal, temporal, and occipital cortical areas (V). In order to more rapidly characterize the underlying anatomy of these segments, this study used a novel single-shot T1 mapping method to quantitatively determine T1 relaxation times in the human CC. A region-of-interest analysis revealed a tendency for the lowest T1 relaxation times in the genu and the highest T1 relaxation times in the somatomotor region of the CC. This observation separates regions dominated by myelinated fibers with large diameters (somatomotor area) from densely packed smaller axonal bundles (genu) with less myelin. The results indicate that characteristic T1 relaxation times in callosal profiles provide an additional means to monitor differences in fiber anatomy, fiber density, and gray matter in respective neocortical areas. In conclusion, rapid T1 mapping allows for a characterization of the axonal architecture in an individual CC in less than 10 s. The approach emerges as a valuable means for studying neocortical brain anatomy with possible implications for the diagnosis of neurodegenerative processes. Frontiers Media S.A. 2015-05-11 /pmc/articles/PMC4426710/ /pubmed/26029059 http://dx.doi.org/10.3389/fnana.2015.00057 Text en Copyright © 2015 Hofer, Wang, Roeloffs and Frahm. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroanatomy Hofer, Sabine Wang, Xiaoqing Roeloffs, Volkert Frahm, Jens Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title | Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title_full | Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title_fullStr | Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title_full_unstemmed | Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title_short | Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
title_sort | single-shot t1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy |
topic | Neuroanatomy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426710/ https://www.ncbi.nlm.nih.gov/pubmed/26029059 http://dx.doi.org/10.3389/fnana.2015.00057 |
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