Cargando…

Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circula...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Chia-Chu, Wu, Chia-Lin, Su, Wei-Wen, Shih, Kai-Lun, Tarng, Der-Cherng, Chou, Chen-Te, Chen, Ting-Yu, Kor, Chew-Teng, Wu, Hung-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426720/
https://www.ncbi.nlm.nih.gov/pubmed/25961500
http://dx.doi.org/10.1038/srep10096
_version_ 1782370627847454720
author Chang, Chia-Chu
Wu, Chia-Lin
Su, Wei-Wen
Shih, Kai-Lun
Tarng, Der-Cherng
Chou, Chen-Te
Chen, Ting-Yu
Kor, Chew-Teng
Wu, Hung-Ming
author_facet Chang, Chia-Chu
Wu, Chia-Lin
Su, Wei-Wen
Shih, Kai-Lun
Tarng, Der-Cherng
Chou, Chen-Te
Chen, Ting-Yu
Kor, Chew-Teng
Wu, Hung-Ming
author_sort Chang, Chia-Chu
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 is associated with the progression of liver disease, and prediabetes in patients with NAFLD. A total of 90 patients with NAFLD alone (n = 48) or NAFLD with incident diabetes (n = 42) and 43 controls participated in this study. Fasting plasma was used to assess metabolic parameters, inflammatory factors, endotoxin levels, and malondialdehyde (MDA) concentrations. Insulin resistance was estimated using homeostatic model assessment (HOMA-IR). IP-10 levels were significantly higher in patients with NAFLD alone (median (interquartile range): 369.44 (309.30–418.97) pg/mL) and in those with incident diabetes (418.99 (330.73–526.04) pg/mL) than in controls (293.37 (214.10–331.57) pg/mL) (P < 0.001). IP-10 levels were positively correlated with levels of alanine aminotransferase, hs-CRP, MDA, MCP-1, and TNF-α as well as HOMA-IR values. Ordinal logistic regression analysis revealed IP-10 was an independent risk factor associated with progressive liver injury, insulin resistance and incident diabetes. Circulating IP-10 may be a non-invasive biomarker for disease progression and subsequent diabetes development of NAFLD.
format Online
Article
Text
id pubmed-4426720
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-44267202015-05-21 Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease Chang, Chia-Chu Wu, Chia-Lin Su, Wei-Wen Shih, Kai-Lun Tarng, Der-Cherng Chou, Chen-Te Chen, Ting-Yu Kor, Chew-Teng Wu, Hung-Ming Sci Rep Article Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 is associated with the progression of liver disease, and prediabetes in patients with NAFLD. A total of 90 patients with NAFLD alone (n = 48) or NAFLD with incident diabetes (n = 42) and 43 controls participated in this study. Fasting plasma was used to assess metabolic parameters, inflammatory factors, endotoxin levels, and malondialdehyde (MDA) concentrations. Insulin resistance was estimated using homeostatic model assessment (HOMA-IR). IP-10 levels were significantly higher in patients with NAFLD alone (median (interquartile range): 369.44 (309.30–418.97) pg/mL) and in those with incident diabetes (418.99 (330.73–526.04) pg/mL) than in controls (293.37 (214.10–331.57) pg/mL) (P < 0.001). IP-10 levels were positively correlated with levels of alanine aminotransferase, hs-CRP, MDA, MCP-1, and TNF-α as well as HOMA-IR values. Ordinal logistic regression analysis revealed IP-10 was an independent risk factor associated with progressive liver injury, insulin resistance and incident diabetes. Circulating IP-10 may be a non-invasive biomarker for disease progression and subsequent diabetes development of NAFLD. Nature Publishing Group 2015-05-11 /pmc/articles/PMC4426720/ /pubmed/25961500 http://dx.doi.org/10.1038/srep10096 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chang, Chia-Chu
Wu, Chia-Lin
Su, Wei-Wen
Shih, Kai-Lun
Tarng, Der-Cherng
Chou, Chen-Te
Chen, Ting-Yu
Kor, Chew-Teng
Wu, Hung-Ming
Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title_full Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title_fullStr Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title_full_unstemmed Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title_short Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
title_sort interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426720/
https://www.ncbi.nlm.nih.gov/pubmed/25961500
http://dx.doi.org/10.1038/srep10096
work_keys_str_mv AT changchiachu interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT wuchialin interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT suweiwen interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT shihkailun interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT tarngdercherng interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT chouchente interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT chentingyu interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT korchewteng interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease
AT wuhungming interferongammainducedprotein10isassociatedwithinsulinresistanceandincidentdiabetesinpatientswithnonalcoholicfattyliverdisease