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Delirium from the gliocentric perspective

Delirium is an acute state marked by disturbances in cognition, attention, memory, perception, and sleep-wake cycle which is common in elderly. Others have shown an association between delirium and increased mortality, length of hospitalization, cost, and discharge to extended stay facilities. Until...

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Autores principales: Sfera, Adonis, Osorio, Carolina, Price, Amy I., Gradini, Roberto, Cummings, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426724/
https://www.ncbi.nlm.nih.gov/pubmed/26029046
http://dx.doi.org/10.3389/fncel.2015.00171
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author Sfera, Adonis
Osorio, Carolina
Price, Amy I.
Gradini, Roberto
Cummings, Michael
author_facet Sfera, Adonis
Osorio, Carolina
Price, Amy I.
Gradini, Roberto
Cummings, Michael
author_sort Sfera, Adonis
collection PubMed
description Delirium is an acute state marked by disturbances in cognition, attention, memory, perception, and sleep-wake cycle which is common in elderly. Others have shown an association between delirium and increased mortality, length of hospitalization, cost, and discharge to extended stay facilities. Until recently it was not known that after an episode of delirium in elderly, there is a 63% probability of developing dementia at 48 months compared to 8% in patients without delirium. Currently there are no preventive therapies for delirium, thus elucidation of cellular and molecular underpinnings of this condition may lead to the development of early interventions and thus prevent permanent cognitive damage. In this article we make the case for the role of glia in the pathophysiology of delirium and describe an astrocyte-dependent central and peripheral cholinergic anti-inflammatory shield which may be disabled by astrocytic pathology, leading to neuroinflammation and delirium. We also touch on the role of glia in information processing and neuroimaging.
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spelling pubmed-44267242015-05-29 Delirium from the gliocentric perspective Sfera, Adonis Osorio, Carolina Price, Amy I. Gradini, Roberto Cummings, Michael Front Cell Neurosci Neuroscience Delirium is an acute state marked by disturbances in cognition, attention, memory, perception, and sleep-wake cycle which is common in elderly. Others have shown an association between delirium and increased mortality, length of hospitalization, cost, and discharge to extended stay facilities. Until recently it was not known that after an episode of delirium in elderly, there is a 63% probability of developing dementia at 48 months compared to 8% in patients without delirium. Currently there are no preventive therapies for delirium, thus elucidation of cellular and molecular underpinnings of this condition may lead to the development of early interventions and thus prevent permanent cognitive damage. In this article we make the case for the role of glia in the pathophysiology of delirium and describe an astrocyte-dependent central and peripheral cholinergic anti-inflammatory shield which may be disabled by astrocytic pathology, leading to neuroinflammation and delirium. We also touch on the role of glia in information processing and neuroimaging. Frontiers Media S.A. 2015-05-11 /pmc/articles/PMC4426724/ /pubmed/26029046 http://dx.doi.org/10.3389/fncel.2015.00171 Text en Copyright © 2015 Sfera, Osorio, Price, Gradini and Cummings. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sfera, Adonis
Osorio, Carolina
Price, Amy I.
Gradini, Roberto
Cummings, Michael
Delirium from the gliocentric perspective
title Delirium from the gliocentric perspective
title_full Delirium from the gliocentric perspective
title_fullStr Delirium from the gliocentric perspective
title_full_unstemmed Delirium from the gliocentric perspective
title_short Delirium from the gliocentric perspective
title_sort delirium from the gliocentric perspective
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426724/
https://www.ncbi.nlm.nih.gov/pubmed/26029046
http://dx.doi.org/10.3389/fncel.2015.00171
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