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Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis

Treatment with tissue plasminogen activator (tPA) beyond the therapeutic time window (>4.5 hours post stroke) may produce hemorrhagic transformation (HT). Strategies that could extend the narrow time window of tPA will benefit a significant number of stroke patients. Male Sprague–Dawley rats unde...

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Detalles Bibliográficos
Autores principales:	dela Peña, Ike C, Yoo, Arum, Tajiri, Naoki, Acosta, Sandra A, Ji, Xunming, Kaneko, Yuji, Borlongan, Cesar V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426753/ https://www.ncbi.nlm.nih.gov/pubmed/25425079 http://dx.doi.org/10.1038/jcbfm.2014.208

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