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EZH2 Modulates Angiogenesis In Vitro and in a Mouse Model of Limb Ischemia
Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription. We explored (i) if EZH2 expre...
Autores principales: | Mitić, Tijana, Caporali, Andrea, Floris, Ilaria, Meloni, Marco, Marchetti, Micol, Urrutia, Raul, Angelini, Gianni D, Emanueli, Costanza |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426795/ https://www.ncbi.nlm.nih.gov/pubmed/25189741 http://dx.doi.org/10.1038/mt.2014.163 |
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