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EZH2 Modulates Angiogenesis In Vitro and in a Mouse Model of Limb Ischemia

Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription. We explored (i) if EZH2 expre...

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Detalles Bibliográficos
Autores principales:	Mitić, Tijana, Caporali, Andrea, Floris, Ilaria, Meloni, Marco, Marchetti, Micol, Urrutia, Raul, Angelini, Gianni D, Emanueli, Costanza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426795/ https://www.ncbi.nlm.nih.gov/pubmed/25189741 http://dx.doi.org/10.1038/mt.2014.163

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