The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsi...

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Detalles Bibliográficos
Autores principales: Ueki, Norikazu, Takeda, Satoru, Koya, Daisuke, Kanasaki, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426891/
https://www.ncbi.nlm.nih.gov/pubmed/26000015
http://dx.doi.org/10.1155/2015/572713
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author Ueki, Norikazu
Takeda, Satoru
Koya, Daisuke
Kanasaki, Keizo
author_facet Ueki, Norikazu
Takeda, Satoru
Koya, Daisuke
Kanasaki, Keizo
author_sort Ueki, Norikazu
collection PubMed
description Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy.
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spelling pubmed-44268912015-05-21 The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia Ueki, Norikazu Takeda, Satoru Koya, Daisuke Kanasaki, Keizo Int J Endocrinol Review Article Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy. Hindawi Publishing Corporation 2015 2015-04-27 /pmc/articles/PMC4426891/ /pubmed/26000015 http://dx.doi.org/10.1155/2015/572713 Text en Copyright © 2015 Norikazu Ueki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ueki, Norikazu
Takeda, Satoru
Koya, Daisuke
Kanasaki, Keizo
The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title_full The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title_fullStr The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title_full_unstemmed The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title_short The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia
title_sort relevance of the renin-angiotensin system in the development of drugs to combat preeclampsia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426891/
https://www.ncbi.nlm.nih.gov/pubmed/26000015
http://dx.doi.org/10.1155/2015/572713
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