AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts

Apurinic/apyrimidinic (AP) endonuclease (Apex) is required for base excision repair (BER), which is the major mechanism of repair for small DNA lesions such as alkylated bases. Apex incises the DNA strand at an AP site to leave 3′-OH and 5′-deoxyribose phosphate (5′-dRp) termini. DNA polymerase β (P...

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Detalles Bibliográficos
Autores principales: Yamamoto, Ryohei, Umetsu, Makio, Yamamoto, Mizuki, Matsuyama, Satoshi, Takenaka, Shigeo, Ide, Hiroshi, Kubo, Kihei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426919/
https://www.ncbi.nlm.nih.gov/pubmed/25724755
http://dx.doi.org/10.1093/jrr/rru125

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