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Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method

We adapted the deformable image registration (DIR) technique to accurately calculate the cumulative intracavitary brachytherapy (ICBT) and external beam radiotherapy (EBRT) rectal dose for treating uterine cervical cancer. A total of 14 patients with primary cervical cancer radically treated with IC...

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Autores principales: Hayashi, Kazuhiko, Isohashi, Fumiaki, Akino, Yuichi, Wakai, Nobuhide, Mabuchi, Seiji, Suzuki, Osamu, Seo, Yuji, Ootani, Yuki, Sumida, Iori, Yoshioka, Yasuo, Kimura, Tadashi, Ogawa, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426921/
https://www.ncbi.nlm.nih.gov/pubmed/25678538
http://dx.doi.org/10.1093/jrr/rru127
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author Hayashi, Kazuhiko
Isohashi, Fumiaki
Akino, Yuichi
Wakai, Nobuhide
Mabuchi, Seiji
Suzuki, Osamu
Seo, Yuji
Ootani, Yuki
Sumida, Iori
Yoshioka, Yasuo
Kimura, Tadashi
Ogawa, Kazuhiko
author_facet Hayashi, Kazuhiko
Isohashi, Fumiaki
Akino, Yuichi
Wakai, Nobuhide
Mabuchi, Seiji
Suzuki, Osamu
Seo, Yuji
Ootani, Yuki
Sumida, Iori
Yoshioka, Yasuo
Kimura, Tadashi
Ogawa, Kazuhiko
author_sort Hayashi, Kazuhiko
collection PubMed
description We adapted the deformable image registration (DIR) technique to accurately calculate the cumulative intracavitary brachytherapy (ICBT) and external beam radiotherapy (EBRT) rectal dose for treating uterine cervical cancer. A total of 14 patients with primary cervical cancer radically treated with ICRT and EBRT were analysed using the Velocity AI(TM) software. Computed tomography (CT) images were registered, and EBRT and ICBT dose distributions were determined. Cumulative D(2cm)(3), D(1cm)(3) and D(0.1cm)(3) were calculated by simple addition of fractional values or by DIR. The accuracy of DIR was evaluated by means of a virtual phantom mimicking the rectum. The dice similarity coefficient (DSC) was calculated to evaluate rectal contour concordance between CT images before and after DIR. Virtual phantom analysis revealed that the average difference between the DIR-based phantom D(mean) and the simple phantom D(mean) was 1.9 ± 2.5 Gy (EQD(2)), and the DIR method included an uncertainty of ∼8.0%. The mean DSC between reference CT and CT was significantly improved after DIR (EBRT: 0.43 vs 0.85, P < 0.005; ICBT: 0.60 vs 0.87, P < 0.005). The average simple rectal D(2cm)(3), D(1cm)(3) and D(0.1cm)(3) values were 77.6, 81.6 and 91.1 Gy (EQD(2)), respectively; the DIR-based values were 76.2, 79.5 and 87.6 Gy, respectively. The simple addition values were overestimated, on average, by 3.1, 3.7 and 5.5 Gy, respectively, relative to the DIR-based values. In conclusion, the difference between the simple rectal dose–volume histogram (DVH) parameter addition and DIR-based cumulative rectal doses increased with decreasing DVH parameters.
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spelling pubmed-44269212015-05-15 Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method Hayashi, Kazuhiko Isohashi, Fumiaki Akino, Yuichi Wakai, Nobuhide Mabuchi, Seiji Suzuki, Osamu Seo, Yuji Ootani, Yuki Sumida, Iori Yoshioka, Yasuo Kimura, Tadashi Ogawa, Kazuhiko J Radiat Res Oncology We adapted the deformable image registration (DIR) technique to accurately calculate the cumulative intracavitary brachytherapy (ICBT) and external beam radiotherapy (EBRT) rectal dose for treating uterine cervical cancer. A total of 14 patients with primary cervical cancer radically treated with ICRT and EBRT were analysed using the Velocity AI(TM) software. Computed tomography (CT) images were registered, and EBRT and ICBT dose distributions were determined. Cumulative D(2cm)(3), D(1cm)(3) and D(0.1cm)(3) were calculated by simple addition of fractional values or by DIR. The accuracy of DIR was evaluated by means of a virtual phantom mimicking the rectum. The dice similarity coefficient (DSC) was calculated to evaluate rectal contour concordance between CT images before and after DIR. Virtual phantom analysis revealed that the average difference between the DIR-based phantom D(mean) and the simple phantom D(mean) was 1.9 ± 2.5 Gy (EQD(2)), and the DIR method included an uncertainty of ∼8.0%. The mean DSC between reference CT and CT was significantly improved after DIR (EBRT: 0.43 vs 0.85, P < 0.005; ICBT: 0.60 vs 0.87, P < 0.005). The average simple rectal D(2cm)(3), D(1cm)(3) and D(0.1cm)(3) values were 77.6, 81.6 and 91.1 Gy (EQD(2)), respectively; the DIR-based values were 76.2, 79.5 and 87.6 Gy, respectively. The simple addition values were overestimated, on average, by 3.1, 3.7 and 5.5 Gy, respectively, relative to the DIR-based values. In conclusion, the difference between the simple rectal dose–volume histogram (DVH) parameter addition and DIR-based cumulative rectal doses increased with decreasing DVH parameters. Oxford University Press 2015-05 2015-02-11 /pmc/articles/PMC4426921/ /pubmed/25678538 http://dx.doi.org/10.1093/jrr/rru127 Text en © The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Oncology
Hayashi, Kazuhiko
Isohashi, Fumiaki
Akino, Yuichi
Wakai, Nobuhide
Mabuchi, Seiji
Suzuki, Osamu
Seo, Yuji
Ootani, Yuki
Sumida, Iori
Yoshioka, Yasuo
Kimura, Tadashi
Ogawa, Kazuhiko
Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title_full Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title_fullStr Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title_full_unstemmed Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title_short Estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
title_sort estimation of the total rectal dose of radical external beam and intracavitary radiotherapy for uterine cervical cancer using the deformable image registration method
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426921/
https://www.ncbi.nlm.nih.gov/pubmed/25678538
http://dx.doi.org/10.1093/jrr/rru127
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