EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma

In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its biological function in this malignancy is unknown. Here we provide evidence that NKX2-2 mediates the EWS/FLI-controlled block of mesenchymal feature...

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Detalles Bibliográficos
Autores principales: Fadul, John, Bell, Russell, Hoffman, Laura M., Beckerle, Mary C., Engel, Michael E., Lessnick, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426950/
https://www.ncbi.nlm.nih.gov/pubmed/26000096

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