Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells

Adult stem cells have a great potential applicability in regenerative medicine and cell-based therapies. However, there are still many unresolved issues concerning their biology, and the influence of the local microenvironment on properties of stem cells has been increasingly recognized. Interleukin...

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Detalles Bibliográficos
Autores principales: Mojsilović, Slavko, Jauković, Aleksandra, Santibañez, Juan F., Bugarski, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427009/
https://www.ncbi.nlm.nih.gov/pubmed/25999667
http://dx.doi.org/10.1155/2015/470458
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author Mojsilović, Slavko
Jauković, Aleksandra
Santibañez, Juan F.
Bugarski, Diana
author_facet Mojsilović, Slavko
Jauković, Aleksandra
Santibañez, Juan F.
Bugarski, Diana
author_sort Mojsilović, Slavko
collection PubMed
description Adult stem cells have a great potential applicability in regenerative medicine and cell-based therapies. However, there are still many unresolved issues concerning their biology, and the influence of the local microenvironment on properties of stem cells has been increasingly recognized. Interleukin (IL-) 17, as a cytokine implicated in many physiological and pathological processes, should be taken into consideration as a part of a regulatory network governing tissue-associated stem cells' fate. This review is focusing on the published data on the effects of IL-17 on the properties and function of hematopoietic and mesenchymal stem cells and trying to discuss that IL-17 achieves many of its roles by acting on adult stem cells.
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spelling pubmed-44270092015-05-21 Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells Mojsilović, Slavko Jauković, Aleksandra Santibañez, Juan F. Bugarski, Diana Mediators Inflamm Review Article Adult stem cells have a great potential applicability in regenerative medicine and cell-based therapies. However, there are still many unresolved issues concerning their biology, and the influence of the local microenvironment on properties of stem cells has been increasingly recognized. Interleukin (IL-) 17, as a cytokine implicated in many physiological and pathological processes, should be taken into consideration as a part of a regulatory network governing tissue-associated stem cells' fate. This review is focusing on the published data on the effects of IL-17 on the properties and function of hematopoietic and mesenchymal stem cells and trying to discuss that IL-17 achieves many of its roles by acting on adult stem cells. Hindawi Publishing Corporation 2015 2015-04-27 /pmc/articles/PMC4427009/ /pubmed/25999667 http://dx.doi.org/10.1155/2015/470458 Text en Copyright © 2015 Slavko Mojsilović et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mojsilović, Slavko
Jauković, Aleksandra
Santibañez, Juan F.
Bugarski, Diana
Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title_full Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title_fullStr Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title_full_unstemmed Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title_short Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
title_sort interleukin-17 and its implication in the regulation of differentiation and function of hematopoietic and mesenchymal stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427009/
https://www.ncbi.nlm.nih.gov/pubmed/25999667
http://dx.doi.org/10.1155/2015/470458
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