Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism

PURPOSE: Leucine activates SIRT1/AMP-activated protein kinase (AMPK) signaling and markedly potentiates the effects of other sirtuin and AMPK activators on insulin signaling and lipid metabolism. Phosphodiesterase 5 inhibition increases nitric oxide–cGMP signaling, which in turn exhibits a positive...

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Detalles Bibliográficos
Autores principales: Fu, Lizhi, Li, Fenfen, Bruckbauer, Antje, Cao, Qiang, Cui, Xin, Wu, Rui, Shi, Hang, Xue, Bingzhong, Zemel, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427070/
https://www.ncbi.nlm.nih.gov/pubmed/25999751
http://dx.doi.org/10.2147/DMSO.S82338

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