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Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin
Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood. Here, we demonstrated that the invasion and metastasis of colorectal cancer is regulated by Cyclin B1. Overexpression of Cyclin B1 wa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427130/ https://www.ncbi.nlm.nih.gov/pubmed/25962181 http://dx.doi.org/10.1371/journal.pone.0126875 |
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author | Fang, Yifeng Liang, Xiao Jiang, Wenbin Li, Jianbo Xu, Junfen Cai, Xiujun |
author_facet | Fang, Yifeng Liang, Xiao Jiang, Wenbin Li, Jianbo Xu, Junfen Cai, Xiujun |
author_sort | Fang, Yifeng |
collection | PubMed |
description | Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood. Here, we demonstrated that the invasion and metastasis of colorectal cancer is regulated by Cyclin B1. Overexpression of Cyclin B1 was observed in colorectal cancer tissues, but this elevated expression was negatively associated with lymph node metastasis, distant metastasis stage, and TNM stage. The Kaplan-Meier survival analysis proved that low Cyclin B1 expression was associated with poor overall survival of patients with colorectal cancer. Inhibition of Cyclin B1 in colorectal cancer cells enhanced the cell migration and invasion of three different colorectal cancer cell lines. In studying the possible mechanism by which Cyclin B1 suppresses colorectal cancer invasion and metastasis, we observed that suppression of Cyclin B1 decreased the expression of E-cadherin protein level. Our findings suggest that Cyclin B1 could suppress the invasion and metastasis of colorectal cancer cells through regulating E-cadherin expression, which enables the development of potential intervention strategies for colorectal cancer. |
format | Online Article Text |
id | pubmed-4427130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44271302015-05-21 Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin Fang, Yifeng Liang, Xiao Jiang, Wenbin Li, Jianbo Xu, Junfen Cai, Xiujun PLoS One Research Article Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood. Here, we demonstrated that the invasion and metastasis of colorectal cancer is regulated by Cyclin B1. Overexpression of Cyclin B1 was observed in colorectal cancer tissues, but this elevated expression was negatively associated with lymph node metastasis, distant metastasis stage, and TNM stage. The Kaplan-Meier survival analysis proved that low Cyclin B1 expression was associated with poor overall survival of patients with colorectal cancer. Inhibition of Cyclin B1 in colorectal cancer cells enhanced the cell migration and invasion of three different colorectal cancer cell lines. In studying the possible mechanism by which Cyclin B1 suppresses colorectal cancer invasion and metastasis, we observed that suppression of Cyclin B1 decreased the expression of E-cadherin protein level. Our findings suggest that Cyclin B1 could suppress the invasion and metastasis of colorectal cancer cells through regulating E-cadherin expression, which enables the development of potential intervention strategies for colorectal cancer. Public Library of Science 2015-05-11 /pmc/articles/PMC4427130/ /pubmed/25962181 http://dx.doi.org/10.1371/journal.pone.0126875 Text en © 2015 Fang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Fang, Yifeng Liang, Xiao Jiang, Wenbin Li, Jianbo Xu, Junfen Cai, Xiujun Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title | Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title_full | Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title_fullStr | Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title_full_unstemmed | Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title_short | Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin |
title_sort | cyclin b1 suppresses colorectal cancer invasion and metastasis by regulating e-cadherin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427130/ https://www.ncbi.nlm.nih.gov/pubmed/25962181 http://dx.doi.org/10.1371/journal.pone.0126875 |
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