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Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

Trypanosoma brucei N-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis. Pyrazole sulfonamide (DDD85646), a potent inhibitor of TbNMT, has been identified in previous studies; however, poor central nervous system exposure restricts its...

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Detalles Bibliográficos
Autores principales:	Robinson, David A., Wyatt, Paul G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2015
Materias:	Molecular Parasitology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427169/ https://www.ncbi.nlm.nih.gov/pubmed/25945713 http://dx.doi.org/10.1107/S2053230X15003040

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