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Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK

PURPOSE: To explore public attitudes towards modifying frequency of mammography screening based on genetic risk. METHODS: Home-based interviews were carried out with a population-based sample of 942 women aged 18–74 years in the UK. Demographic characteristics and perceived breast cancer (BC) risk w...

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Autores principales: Meisel, Susanne F., Pashayan, Nora, Rahman, Belinda, Side, Lucy, Fraser, Lindsay, Gessler, Sue, Lanceley, Anne, Wardle, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427278/
https://www.ncbi.nlm.nih.gov/pubmed/25708717
http://dx.doi.org/10.1016/j.breast.2015.02.001
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author Meisel, Susanne F.
Pashayan, Nora
Rahman, Belinda
Side, Lucy
Fraser, Lindsay
Gessler, Sue
Lanceley, Anne
Wardle, Jane
author_facet Meisel, Susanne F.
Pashayan, Nora
Rahman, Belinda
Side, Lucy
Fraser, Lindsay
Gessler, Sue
Lanceley, Anne
Wardle, Jane
author_sort Meisel, Susanne F.
collection PubMed
description PURPOSE: To explore public attitudes towards modifying frequency of mammography screening based on genetic risk. METHODS: Home-based interviews were carried out with a population-based sample of 942 women aged 18–74 years in the UK. Demographic characteristics and perceived breast cancer (BC) risk were examined as predictors of support for risk-stratified BC screening and of the acceptability of raised or lowered screening frequency based on genetic risk, using multivariate logistic regression. RESULTS: Over two-thirds of respondents (65.8%) supported the idea of varying screening frequency on the basis of genetic risk. The majority (85.4%) were willing to have more frequent breast screening if they were found to be at higher risk, but fewer (58.8%) were willing to have less frequent screening if at lower risk (t (956) = 15.6, p < 0.001). Ethnic minority status was associated with less acceptability of more frequent screening (OR = 0.40, 95% CI = 0.21–0.74), but there were no other significant demographic correlates. Higher perceived risk of BC was associated with greater acceptability of more frequent screening (OR = 1.71, 95%CI = 1.27–2.30). CONCLUSION: Women were positive about adjusting the frequency of mammography screening in line with personal genetic risk, but it will be important to develop effective communication materials to minimise resistance to reducing screening frequency for those at lower genetic risk.
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spelling pubmed-44272782015-06-01 Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK Meisel, Susanne F. Pashayan, Nora Rahman, Belinda Side, Lucy Fraser, Lindsay Gessler, Sue Lanceley, Anne Wardle, Jane Breast Orginal Article PURPOSE: To explore public attitudes towards modifying frequency of mammography screening based on genetic risk. METHODS: Home-based interviews were carried out with a population-based sample of 942 women aged 18–74 years in the UK. Demographic characteristics and perceived breast cancer (BC) risk were examined as predictors of support for risk-stratified BC screening and of the acceptability of raised or lowered screening frequency based on genetic risk, using multivariate logistic regression. RESULTS: Over two-thirds of respondents (65.8%) supported the idea of varying screening frequency on the basis of genetic risk. The majority (85.4%) were willing to have more frequent breast screening if they were found to be at higher risk, but fewer (58.8%) were willing to have less frequent screening if at lower risk (t (956) = 15.6, p < 0.001). Ethnic minority status was associated with less acceptability of more frequent screening (OR = 0.40, 95% CI = 0.21–0.74), but there were no other significant demographic correlates. Higher perceived risk of BC was associated with greater acceptability of more frequent screening (OR = 1.71, 95%CI = 1.27–2.30). CONCLUSION: Women were positive about adjusting the frequency of mammography screening in line with personal genetic risk, but it will be important to develop effective communication materials to minimise resistance to reducing screening frequency for those at lower genetic risk. Elsevier 2015-06 /pmc/articles/PMC4427278/ /pubmed/25708717 http://dx.doi.org/10.1016/j.breast.2015.02.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Orginal Article
Meisel, Susanne F.
Pashayan, Nora
Rahman, Belinda
Side, Lucy
Fraser, Lindsay
Gessler, Sue
Lanceley, Anne
Wardle, Jane
Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title_full Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title_fullStr Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title_full_unstemmed Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title_short Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK
title_sort adjusting the frequency of mammography screening on the basis of genetic risk: attitudes among women in the uk
topic Orginal Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427278/
https://www.ncbi.nlm.nih.gov/pubmed/25708717
http://dx.doi.org/10.1016/j.breast.2015.02.001
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