Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a downstream effector and an upstream mediator of pathways involved in growth and inflammation, and has long been viewed as a...

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Detalles Bibliográficos
Autores principales: Marshall, Derek C., Lyman, Susan K., McCauley, Scott, Kovalenko, Maria, Spangler, Rhyannon, Liu, Chian, Lee, Michael, O’Sullivan, Christopher, Barry-Hamilton, Vivian, Ghermazien, Haben, Mikels-Vigdal, Amanda, Garcia, Carlos A., Jorgensen, Brett, Velayo, Arleene C., Wang, Ruth, Adamkewicz, Joanne I., Smith, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427291/
https://www.ncbi.nlm.nih.gov/pubmed/25961845
http://dx.doi.org/10.1371/journal.pone.0127063

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