An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling

BACKGROUND: Lung cancer is emerging rapidly as the leading death cause in Chinese cancer patients. The causal factors for Chinese lung cancer development remain largely unclear. Here we employed an shRNA library-based loss-of-function screen in a genome-wide and unbiased manner to interrogate potent...

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Detalles Bibliográficos
Autores principales: Xu, Hui, Sun, Huiying, Zhang, Haiyuan, Liu, Jiawei, Fan, Fangfang, Li, Yilan, Ning, Xuelian, Sun, Yue, Dai, Shaochun, Liu, Baogang, Gao, Min, Fu, Songbin, Zhou, Chunshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427398/
https://www.ncbi.nlm.nih.gov/pubmed/25962159
http://dx.doi.org/10.1371/journal.pone.0124033

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