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Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method

BACKGROUND: Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that causes severe human health problems. To develop a new chemotherapeutic agent for the treatment of Chagas disease, we predicted a pharmacophore model for T. cruzi dihydroorotate dehydrogenase (T...

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Detalles Bibliográficos
Autores principales:	Yoshino, Ryunosuke, Yasuo, Nobuaki, Inaoka, Daniel Ken, Hagiwara, Yohsuke, Ohno, Kazuki, Orita, Masaya, Inoue, Masayuki, Shiba, Tomoo, Harada, Shigeharu, Honma, Teruki, Balogun, Emmanuel Oluwadare, da Rocha, Josmar Rodrigues, Montanari, Carlos Alberto, Kita, Kiyoshi, Sekijima, Masakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427443/ https://www.ncbi.nlm.nih.gov/pubmed/25961853 http://dx.doi.org/10.1371/journal.pone.0125829

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