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The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease
BACKGROUND: Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427594/ https://www.ncbi.nlm.nih.gov/pubmed/26005340 http://dx.doi.org/10.2147/COPD.S80439 |
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author | Kim, Yeon Wook Jin, Kwang-Nam Heo, Eun Young Park, Sung Soo Chung, Hee Soon Kim, Deog Kyeom |
author_facet | Kim, Yeon Wook Jin, Kwang-Nam Heo, Eun Young Park, Sung Soo Chung, Hee Soon Kim, Deog Kyeom |
author_sort | Kim, Yeon Wook |
collection | PubMed |
description | BACKGROUND: Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway inflammatory disease. This study evaluated the association between bronchiectasis and lung cancer in patients with COPD. METHODS: A matched case–control study was conducted in a referral hospital in South Korea. Among COPD patients with moderate to very severe airflow limitation (forced expiratory volume in one second/forced vital capacity <0.7 and forced expiratory volume in one second ≤70% [% predicted]) who underwent chest computed tomography (CT) between January 1, 2010 and May 30, 2013, patients with lung cancer and controls matched for age, sex, and smoking history were selected. The risk of lung cancer was assessed according to the presence of underlying bronchiectasis confirmed by chest CT. RESULTS: The study enrolled 99 cases and 198 controls. Combined bronchiectasis on chest CT was inversely associated with the risk of lung cancer compared with controls (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.12–0.52, P<0.001). Significant associations were found in patients with squamous cell carcinoma (OR 0.11, 95% CI 0.03–0.49, P=0.001) and history of smoking (OR 0.27, 95% CI 0.12–0.57, P<0.001). However, the severity and location of bronchiectasis were not associated with the risk of lung cancer. CONCLUSION: Interestingly, the concomitant presence of bronchiectasis in COPD patients was associated with a lower risk of lung cancer. |
format | Online Article Text |
id | pubmed-4427594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44275942015-05-23 The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease Kim, Yeon Wook Jin, Kwang-Nam Heo, Eun Young Park, Sung Soo Chung, Hee Soon Kim, Deog Kyeom Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway inflammatory disease. This study evaluated the association between bronchiectasis and lung cancer in patients with COPD. METHODS: A matched case–control study was conducted in a referral hospital in South Korea. Among COPD patients with moderate to very severe airflow limitation (forced expiratory volume in one second/forced vital capacity <0.7 and forced expiratory volume in one second ≤70% [% predicted]) who underwent chest computed tomography (CT) between January 1, 2010 and May 30, 2013, patients with lung cancer and controls matched for age, sex, and smoking history were selected. The risk of lung cancer was assessed according to the presence of underlying bronchiectasis confirmed by chest CT. RESULTS: The study enrolled 99 cases and 198 controls. Combined bronchiectasis on chest CT was inversely associated with the risk of lung cancer compared with controls (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.12–0.52, P<0.001). Significant associations were found in patients with squamous cell carcinoma (OR 0.11, 95% CI 0.03–0.49, P=0.001) and history of smoking (OR 0.27, 95% CI 0.12–0.57, P<0.001). However, the severity and location of bronchiectasis were not associated with the risk of lung cancer. CONCLUSION: Interestingly, the concomitant presence of bronchiectasis in COPD patients was associated with a lower risk of lung cancer. Dove Medical Press 2015-05-04 /pmc/articles/PMC4427594/ /pubmed/26005340 http://dx.doi.org/10.2147/COPD.S80439 Text en © 2015 Kim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Kim, Yeon Wook Jin, Kwang-Nam Heo, Eun Young Park, Sung Soo Chung, Hee Soon Kim, Deog Kyeom The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title | The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title_full | The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title_fullStr | The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title_full_unstemmed | The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title_short | The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
title_sort | association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427594/ https://www.ncbi.nlm.nih.gov/pubmed/26005340 http://dx.doi.org/10.2147/COPD.S80439 |
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