Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population

BACKGROUND: Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigat...

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Autores principales: Xu, Chao, Chen, Pingfa, Xie, Hua, Zhu, Hairong, Zhu, Dongmei, Cai, Peng, Huo, Weiwei, Qin, Yufeng, Li, Hongxing, Xia, Yankai, Tang, Weibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427616/
https://www.ncbi.nlm.nih.gov/pubmed/25424204
http://dx.doi.org/10.1007/s10620-014-3450-6
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author Xu, Chao
Chen, Pingfa
Xie, Hua
Zhu, Hairong
Zhu, Dongmei
Cai, Peng
Huo, Weiwei
Qin, Yufeng
Li, Hongxing
Xia, Yankai
Tang, Weibing
author_facet Xu, Chao
Chen, Pingfa
Xie, Hua
Zhu, Hairong
Zhu, Dongmei
Cai, Peng
Huo, Weiwei
Qin, Yufeng
Li, Hongxing
Xia, Yankai
Tang, Weibing
author_sort Xu, Chao
collection PubMed
description BACKGROUND: Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease. METHODS: TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR. RESULTS: We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001). CONCLUSIONS: Our result suggested that CYP2B6 rs707265 modified the risk of HSCR.
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spelling pubmed-44276162015-05-14 Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population Xu, Chao Chen, Pingfa Xie, Hua Zhu, Hairong Zhu, Dongmei Cai, Peng Huo, Weiwei Qin, Yufeng Li, Hongxing Xia, Yankai Tang, Weibing Dig Dis Sci Original Article BACKGROUND: Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease. METHODS: TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR. RESULTS: We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001). CONCLUSIONS: Our result suggested that CYP2B6 rs707265 modified the risk of HSCR. Springer US 2014-11-26 2015 /pmc/articles/PMC4427616/ /pubmed/25424204 http://dx.doi.org/10.1007/s10620-014-3450-6 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Xu, Chao
Chen, Pingfa
Xie, Hua
Zhu, Hairong
Zhu, Dongmei
Cai, Peng
Huo, Weiwei
Qin, Yufeng
Li, Hongxing
Xia, Yankai
Tang, Weibing
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title_full Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title_fullStr Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title_full_unstemmed Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title_short Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population
title_sort associations between cyp2b6 rs707265, rs1042389, rs2054675, and hirschsprung disease in a chinese population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427616/
https://www.ncbi.nlm.nih.gov/pubmed/25424204
http://dx.doi.org/10.1007/s10620-014-3450-6
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