A CT60G>A polymorphism in the CTLA-4 gene of the recipient may confer susceptibility to acute graft versus host disease after allogeneic hematopoietic stem cell transplantation

T cell activation plays a crucial role in the development of acute graft versus host disease (aGvHD). Cytotoxic T cell antigen-4 (CTLA-4) is a co-inhibitory molecule that negatively regulates T cell activation, differentiation, and proliferation. Single-nucleotide polymorphisms (SNPs) in CTLA-4 gene...

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Detalles Bibliográficos
Autores principales: Karabon, Lidia, Markiewicz, Miroslaw, Partyka, Anna, Pawlak-Adamska, Edyta, Tomkiewicz, Anna, Dzierzak-Mietla, Monika, Kyrcz-Krzemien, Slawomira, Frydecka, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427628/
https://www.ncbi.nlm.nih.gov/pubmed/25940108
http://dx.doi.org/10.1007/s00251-015-0840-7

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