Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops lung tumors spontaneously. Moreover, there is a consider...

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Detalles Bibliográficos
Autores principales: Luettich, Karsta, Xiang, Yang, Iskandar, Anita, Sewer, Alain, Martin, Florian, Talikka, Marja, Vanscheeuwijck, Patrick, Berges, An, Veljkovic, Emilija, Gonzalez-Suarez, Ignacio, Schlage, Walter, Hoeng, Julia, Peitsch, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427718/
https://www.ncbi.nlm.nih.gov/pubmed/26109882
http://dx.doi.org/10.2478/intox-2014-0010

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