Megakaryocyte rupture for acute platelet needs

Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410052) show that platelet release from megakaryocytes can be induced by interleukin-1α (IL-1α) via a new r...

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Detalles Bibliográficos
Autores principales: Nieswandt, Bernhard, Stritt, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427795/
https://www.ncbi.nlm.nih.gov/pubmed/25963815
http://dx.doi.org/10.1083/jcb.201504026
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author Nieswandt, Bernhard
Stritt, Simon
author_facet Nieswandt, Bernhard
Stritt, Simon
author_sort Nieswandt, Bernhard
collection PubMed
description Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410052) show that platelet release from megakaryocytes can be induced by interleukin-1α (IL-1α) via a new rupture mechanism, which yields higher platelet numbers, occurs independently of the key regulator of megakaryopoiesis thrombopoietin, and may occur during situations of acute platelet need.
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spelling pubmed-44277952015-11-11 Megakaryocyte rupture for acute platelet needs Nieswandt, Bernhard Stritt, Simon J Cell Biol Reviews Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410052) show that platelet release from megakaryocytes can be induced by interleukin-1α (IL-1α) via a new rupture mechanism, which yields higher platelet numbers, occurs independently of the key regulator of megakaryopoiesis thrombopoietin, and may occur during situations of acute platelet need. The Rockefeller University Press 2015-05-11 /pmc/articles/PMC4427795/ /pubmed/25963815 http://dx.doi.org/10.1083/jcb.201504026 Text en © 2015 Nieswandt and Stritt This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Nieswandt, Bernhard
Stritt, Simon
Megakaryocyte rupture for acute platelet needs
title Megakaryocyte rupture for acute platelet needs
title_full Megakaryocyte rupture for acute platelet needs
title_fullStr Megakaryocyte rupture for acute platelet needs
title_full_unstemmed Megakaryocyte rupture for acute platelet needs
title_short Megakaryocyte rupture for acute platelet needs
title_sort megakaryocyte rupture for acute platelet needs
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427795/
https://www.ncbi.nlm.nih.gov/pubmed/25963815
http://dx.doi.org/10.1083/jcb.201504026
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