FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

BACKGROUND: Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We reported on a novel camptothecin analogue, FL118, which shows anticancer activity...

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Detalles Bibliográficos
Autores principales: Westover, David, Ling, Xiang, Lam, Hong, Welch, Jacob, Jin, Chunyang, Gongora, Celine, Del Rio, Maguy, Wani, Mansukh, Li, Fengzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427926/
https://www.ncbi.nlm.nih.gov/pubmed/25928015
http://dx.doi.org/10.1186/s12943-015-0362-9

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