Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation

BACKGROUND: The Forkhead box M1 (FOXM1) is an oncogenic transcription factor and plays a significant role in cell EMT, proliferation, metastasis in a multitude of human solid tumors including colorectal cancer (CRC). However, the underlying molecular mechanisms by which FoxM1 contributes to epitheli...

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Detalles Bibliográficos
Autores principales: Yang, KanKan, Jiang, LinHua, Hu, You, Yu, Jing, Chen, HenFeng, Yao, YiZhou, Zhu, XinGuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427949/
https://www.ncbi.nlm.nih.gov/pubmed/25935853
http://dx.doi.org/10.1186/s13046-015-0158-1

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