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Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effe...

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Autores principales: Golberg, Alexander, Khan, Saiqa, Belov, Vasily, Quinn, Kyle P., Albadawi, Hassan, Felix Broelsch, G., Watkins, Michael T., Georgakoudi, Irene, Papisov, Mikhail, Mihm Jr., Martin C., Austen Jr., William G., Yarmush, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428072/
https://www.ncbi.nlm.nih.gov/pubmed/25965851
http://dx.doi.org/10.1038/srep10187
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author Golberg, Alexander
Khan, Saiqa
Belov, Vasily
Quinn, Kyle P.
Albadawi, Hassan
Felix Broelsch, G.
Watkins, Michael T.
Georgakoudi, Irene
Papisov, Mikhail
Mihm Jr., Martin C.
Austen Jr., William G.
Yarmush, Martin L.
author_facet Golberg, Alexander
Khan, Saiqa
Belov, Vasily
Quinn, Kyle P.
Albadawi, Hassan
Felix Broelsch, G.
Watkins, Michael T.
Georgakoudi, Irene
Papisov, Mikhail
Mihm Jr., Martin C.
Austen Jr., William G.
Yarmush, Martin L.
author_sort Golberg, Alexander
collection PubMed
description Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.
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spelling pubmed-44280722015-05-21 Skin Rejuvenation with Non-Invasive Pulsed Electric Fields Golberg, Alexander Khan, Saiqa Belov, Vasily Quinn, Kyle P. Albadawi, Hassan Felix Broelsch, G. Watkins, Michael T. Georgakoudi, Irene Papisov, Mikhail Mihm Jr., Martin C. Austen Jr., William G. Yarmush, Martin L. Sci Rep Article Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. Nature Publishing Group 2015-05-12 /pmc/articles/PMC4428072/ /pubmed/25965851 http://dx.doi.org/10.1038/srep10187 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Golberg, Alexander
Khan, Saiqa
Belov, Vasily
Quinn, Kyle P.
Albadawi, Hassan
Felix Broelsch, G.
Watkins, Michael T.
Georgakoudi, Irene
Papisov, Mikhail
Mihm Jr., Martin C.
Austen Jr., William G.
Yarmush, Martin L.
Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title_full Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title_fullStr Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title_full_unstemmed Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title_short Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
title_sort skin rejuvenation with non-invasive pulsed electric fields
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428072/
https://www.ncbi.nlm.nih.gov/pubmed/25965851
http://dx.doi.org/10.1038/srep10187
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