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Computational re-engineering of Amylin sequence with reduced amyloidogenic potential
BACKGROUND: The aggregation of amyloid proteins into fibrils is associated with neurodegenerative diseases such as Alzheimer’s and Type II Diabetes. Different methods have explored ways to impede and inhibit amyloid aggregation. Most attempts in the literature involve applying stress to the environm...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428086/ https://www.ncbi.nlm.nih.gov/pubmed/25903685 http://dx.doi.org/10.1186/s12900-015-0034-4 |