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Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring

Individuals with major depressive disorder (MDD) often ruminate about past experiences, especially those with negative content. These repetitive thoughts may interfere with cognitive processes related to attention and conflict monitoring. However, the temporal nature of these processes as reflected...

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Autores principales: Alderman, Brandon L., Olson, Ryan L., Bates, Marsha E., Selby, Edward A., Buckman, Jennifer F., Brush, Christopher J., Panza, Emily A., Kranzler, Amy, Eddie, David, Shors, Tracey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428129/
https://www.ncbi.nlm.nih.gov/pubmed/26029086
http://dx.doi.org/10.3389/fnhum.2015.00269
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author Alderman, Brandon L.
Olson, Ryan L.
Bates, Marsha E.
Selby, Edward A.
Buckman, Jennifer F.
Brush, Christopher J.
Panza, Emily A.
Kranzler, Amy
Eddie, David
Shors, Tracey J.
author_facet Alderman, Brandon L.
Olson, Ryan L.
Bates, Marsha E.
Selby, Edward A.
Buckman, Jennifer F.
Brush, Christopher J.
Panza, Emily A.
Kranzler, Amy
Eddie, David
Shors, Tracey J.
author_sort Alderman, Brandon L.
collection PubMed
description Individuals with major depressive disorder (MDD) often ruminate about past experiences, especially those with negative content. These repetitive thoughts may interfere with cognitive processes related to attention and conflict monitoring. However, the temporal nature of these processes as reflected in event-related potentials (ERPs) has not been well-described. We examined behavioral and ERP indices of conflict monitoring during a modified flanker task and the allocation of attention during an attentional blink (AB) task in 33 individuals with MDD and 36 healthy controls, and whether their behavioral performance and ERPs varied with level of rumination. N2 amplitude elicited by the flanker task was significantly reduced in participants with MDD compared to healthy controls. Level of self-reported rumination was also correlated with N2 amplitude. In contrast, P3 amplitude during the AB task was not significantly different between groups, nor was it correlated with rumination. No significant differences were found in behavioral task performance measures between groups or by rumination levels. These findings suggest that rumination in MDD is associated with select deficits in cognitive control, particularly related to conflict monitoring.
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spelling pubmed-44281292015-05-29 Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring Alderman, Brandon L. Olson, Ryan L. Bates, Marsha E. Selby, Edward A. Buckman, Jennifer F. Brush, Christopher J. Panza, Emily A. Kranzler, Amy Eddie, David Shors, Tracey J. Front Hum Neurosci Neuroscience Individuals with major depressive disorder (MDD) often ruminate about past experiences, especially those with negative content. These repetitive thoughts may interfere with cognitive processes related to attention and conflict monitoring. However, the temporal nature of these processes as reflected in event-related potentials (ERPs) has not been well-described. We examined behavioral and ERP indices of conflict monitoring during a modified flanker task and the allocation of attention during an attentional blink (AB) task in 33 individuals with MDD and 36 healthy controls, and whether their behavioral performance and ERPs varied with level of rumination. N2 amplitude elicited by the flanker task was significantly reduced in participants with MDD compared to healthy controls. Level of self-reported rumination was also correlated with N2 amplitude. In contrast, P3 amplitude during the AB task was not significantly different between groups, nor was it correlated with rumination. No significant differences were found in behavioral task performance measures between groups or by rumination levels. These findings suggest that rumination in MDD is associated with select deficits in cognitive control, particularly related to conflict monitoring. Frontiers Media S.A. 2015-05-12 /pmc/articles/PMC4428129/ /pubmed/26029086 http://dx.doi.org/10.3389/fnhum.2015.00269 Text en Copyright © 2015 Alderman, Olson, Bates, Selby, Buckman, Brush, Panza, Kranzler, Eddie and Shors. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Alderman, Brandon L.
Olson, Ryan L.
Bates, Marsha E.
Selby, Edward A.
Buckman, Jennifer F.
Brush, Christopher J.
Panza, Emily A.
Kranzler, Amy
Eddie, David
Shors, Tracey J.
Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title_full Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title_fullStr Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title_full_unstemmed Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title_short Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
title_sort rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428129/
https://www.ncbi.nlm.nih.gov/pubmed/26029086
http://dx.doi.org/10.3389/fnhum.2015.00269
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