Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients

BACKGROUND: Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium. FINDINGS: A prospective cohort of 19 hip fracture patients (m...

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Detalles Bibliográficos
Autores principales: Skrede, Kjersti, Wyller, Torgeir Bruun, Watne, Leiv Otto, Seljeflot, Ingebjørg, Juliebø, Vibeke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428231/
https://www.ncbi.nlm.nih.gov/pubmed/25943983
http://dx.doi.org/10.1186/s13104-015-1129-5
Descripción
Sumario:BACKGROUND: Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium. FINDINGS: A prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03). CONCLUSIONS: MCP-1 might play a role in the development of delirium.

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