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TCR ITAM multiplicity is required for the generation of follicular helper T-cells

The T-cell antigen receptor (TCR) complex contains 10 copies of a di-tyrosine Immunoreceptor-Tyrosine-based-Activation-Motif (ITAM) that initiates TCR signalling by recruiting protein tyrosine kinases. ITAM multiplicity amplifies TCR signals, but the importance of this capability for T-cell response...

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Detalles Bibliográficos
Autores principales:	Hwang, SuJin, Palin, Amy C., Li, LiQi, Song, Ki-Duk, Lee, Jan, Herz, Jasmin, Tubo, Noah, Chu, Hamlet, Pepper, Marion, Lesourne, Renaud, Zvezdova, Ekaterina, Pinkhasov, Julia, Jenkins, Marc K., McGavern, Dorian, Love, Paul E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428620/ https://www.ncbi.nlm.nih.gov/pubmed/25959494 http://dx.doi.org/10.1038/ncomms7982

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