Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses cognitive and motor assessment, and neuroimaging of...

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Detalles Bibliográficos
Autores principales: Chan, Anthony W. S., Jiang, Jie, Chen, Yiju, Li, Chunxia, Prucha, Melinda S., Hu, Yijuan, Chi, Tim, Moran, Sean, Rahim, Tayeb, Li, Shihua, Li, Xiaojiang, Zola, Stuart M., Testa, Claudia M., Mao, Hui, Villalba, Rosa, Smith, Yoland, Zhang, Xiaodong, Bachevalier, Jocelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428630/
https://www.ncbi.nlm.nih.gov/pubmed/25966278
http://dx.doi.org/10.1371/journal.pone.0122335

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