Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic and endo...

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Detalles Bibliográficos
Autores principales: Mauvezin, Caroline, Nagy, Péter, Juhász, Gábor, Neufeld, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428688/
https://www.ncbi.nlm.nih.gov/pubmed/25959678
http://dx.doi.org/10.1038/ncomms8007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428688/
https://www.ncbi.nlm.nih.gov/pubmed/25959678
http://dx.doi.org/10.1038/ncomms8007

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