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MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux()

MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. Numerous reports have described modulation of Caco-2 cellular efflux and transport of flavonoids in the presen...

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Detalles Bibliográficos
Autores principales:	Barrington, Robert D., Needs, Paul W., Williamson, Gary, Kroon, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428793/ https://www.ncbi.nlm.nih.gov/pubmed/25801004 http://dx.doi.org/10.1016/j.bcp.2015.03.005

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