Optimization of Translation Profiles Enhances Protein Expression and Solubility

mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to delineate the translation of single domains. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Hess, Anne-Katrin, Saffert, Paul, Liebeton, Klaus, Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428881/
https://www.ncbi.nlm.nih.gov/pubmed/25965266
http://dx.doi.org/10.1371/journal.pone.0127039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428881/
https://www.ncbi.nlm.nih.gov/pubmed/25965266
http://dx.doi.org/10.1371/journal.pone.0127039

Ejemplares similares