DNA repair mechanisms and human cytomegalovirus (HCMV) infection

Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleoti...

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Detalles Bibliográficos
Autores principales: Smolarz, Beata, Wilczyński, Jan, Nowakowska, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429022/
https://www.ncbi.nlm.nih.gov/pubmed/25366712
http://dx.doi.org/10.1007/s12223-014-0359-6
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author Smolarz, Beata
Wilczyński, Jan
Nowakowska, Dorota
author_facet Smolarz, Beata
Wilczyński, Jan
Nowakowska, Dorota
author_sort Smolarz, Beata
collection PubMed
description Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection.
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spelling pubmed-44290222015-05-18 DNA repair mechanisms and human cytomegalovirus (HCMV) infection Smolarz, Beata Wilczyński, Jan Nowakowska, Dorota Folia Microbiol (Praha) Article Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection. Springer Netherlands 2014-11-01 2015 /pmc/articles/PMC4429022/ /pubmed/25366712 http://dx.doi.org/10.1007/s12223-014-0359-6 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Smolarz, Beata
Wilczyński, Jan
Nowakowska, Dorota
DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title_full DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title_fullStr DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title_full_unstemmed DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title_short DNA repair mechanisms and human cytomegalovirus (HCMV) infection
title_sort dna repair mechanisms and human cytomegalovirus (hcmv) infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429022/
https://www.ncbi.nlm.nih.gov/pubmed/25366712
http://dx.doi.org/10.1007/s12223-014-0359-6
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