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Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

Physico-chemical properties of the mutations G34R, P39L and E41K in the N-terminal domain of human heat shock protein B1 (HspB1), which have been associated with hereditary motor neuron neuropathy, were analyzed. Heat-induced aggregation of all mutants started at lower temperatures than for the wild...

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Detalles Bibliográficos
Autores principales:	Muranova, Lydia K., Weeks, Stephen D., Strelkov, Sergei V., Gusev, Nikolai B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429025/ https://www.ncbi.nlm.nih.gov/pubmed/25965061 http://dx.doi.org/10.1371/journal.pone.0126248

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