Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thro...

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Autores principales: Nazha, Bassel, Garcia, Gwenalyn, Kandov, Ruben, Odaimi, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429202/
https://www.ncbi.nlm.nih.gov/pubmed/26064712
http://dx.doi.org/10.1155/2015/161764
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author Nazha, Bassel
Garcia, Gwenalyn
Kandov, Ruben
Odaimi, Marcel
author_facet Nazha, Bassel
Garcia, Gwenalyn
Kandov, Ruben
Odaimi, Marcel
author_sort Nazha, Bassel
collection PubMed
description Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET whose initial disease manifestation was a non-ST segment elevation myocardial infarction.
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spelling pubmed-44292022015-06-10 Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome Nazha, Bassel Garcia, Gwenalyn Kandov, Ruben Odaimi, Marcel Case Rep Hematol Case Report Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET whose initial disease manifestation was a non-ST segment elevation myocardial infarction. Hindawi Publishing Corporation 2015 2015-04-29 /pmc/articles/PMC4429202/ /pubmed/26064712 http://dx.doi.org/10.1155/2015/161764 Text en Copyright © 2015 Bassel Nazha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nazha, Bassel
Garcia, Gwenalyn
Kandov, Ruben
Odaimi, Marcel
Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title_full Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title_fullStr Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title_full_unstemmed Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title_short Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
title_sort calreticulin mutated essential thrombocythemia presenting as acute coronary syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429202/
https://www.ncbi.nlm.nih.gov/pubmed/26064712
http://dx.doi.org/10.1155/2015/161764
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AT kandovruben calreticulinmutatedessentialthrombocythemiapresentingasacutecoronarysyndrome
AT odaimimarcel calreticulinmutatedessentialthrombocythemiapresentingasacutecoronarysyndrome

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