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Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer

BACKGROUND: Lysine-specific demethylase 1(LSD1) is implicated in the tumorigenesis and progression in various cancers. However, the expression of LSD1 in epithelial ovarian cancer and its clinical significance has not been examined in detail. METHODS: Immunohistochemical was used to detect the expre...

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Autores principales: Chen, Cong, Ge, Jing, Lu, Qibin, Ping, Guoqiang, Yang, Chunqing, Fang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429353/
https://www.ncbi.nlm.nih.gov/pubmed/25956476
http://dx.doi.org/10.1186/s13048-015-0155-1
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author Chen, Cong
Ge, Jing
Lu, Qibin
Ping, Guoqiang
Yang, Chunqing
Fang, Xuefeng
author_facet Chen, Cong
Ge, Jing
Lu, Qibin
Ping, Guoqiang
Yang, Chunqing
Fang, Xuefeng
author_sort Chen, Cong
collection PubMed
description BACKGROUND: Lysine-specific demethylase 1(LSD1) is implicated in the tumorigenesis and progression in various cancers. However, the expression of LSD1 in epithelial ovarian cancer and its clinical significance has not been examined in detail. METHODS: Immunohistochemical was used to detect the expression of LSD1 in normal ovarian epithelial tissues, cystadenoma, borderline cystadenoma, and cystadenocarcinoma. Next, the correlations between expression of LSD1 and clinicopathological features was assessed in 96 species of serous cystadenocarcinoma and 36 species of mucinous cystadenocarcinoma. RESULTS: Immunohistochemical results showed that the expression of LSD1 was gradually increased from benign cystadenoma and borderline cystadenoma to cystadenocarcinoma. The positive ratio of LSD1 expression was 50% in normal ovarian epithelial tissues, 72% in serous cystadenoma, 73% in mucinous cystadenoma, 82% in borderline serous cystadenoma, 83% in borderline mucinous cystadenoma, 94% in serous cystadenocarcinoma and 92% in mucinous cystadenocarcinoma, respectively. LSD1 expression levels were associated with International Federation of Gynecology and Obstetrics stage and lymphatic metastasis in both serous and mucinous cystadenocarcinoma samples. Kaplan-Meier curves suggested that overall survival time of patients with high LSD1 expression was significantly shorter than that of patients with low LSD1 expression. Multivariate Cox proportional hazard regression indicated that higher LSD1 expression was a significant independent predictor of poor survival of EOC patients (P = 0.016). CONCLUSIONS: These results suggest that LSD1 may be involved in carcinogenesis and progression with promising therapeutic potential for epithelial ovarian cancer.
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spelling pubmed-44293532015-05-14 Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer Chen, Cong Ge, Jing Lu, Qibin Ping, Guoqiang Yang, Chunqing Fang, Xuefeng J Ovarian Res Research BACKGROUND: Lysine-specific demethylase 1(LSD1) is implicated in the tumorigenesis and progression in various cancers. However, the expression of LSD1 in epithelial ovarian cancer and its clinical significance has not been examined in detail. METHODS: Immunohistochemical was used to detect the expression of LSD1 in normal ovarian epithelial tissues, cystadenoma, borderline cystadenoma, and cystadenocarcinoma. Next, the correlations between expression of LSD1 and clinicopathological features was assessed in 96 species of serous cystadenocarcinoma and 36 species of mucinous cystadenocarcinoma. RESULTS: Immunohistochemical results showed that the expression of LSD1 was gradually increased from benign cystadenoma and borderline cystadenoma to cystadenocarcinoma. The positive ratio of LSD1 expression was 50% in normal ovarian epithelial tissues, 72% in serous cystadenoma, 73% in mucinous cystadenoma, 82% in borderline serous cystadenoma, 83% in borderline mucinous cystadenoma, 94% in serous cystadenocarcinoma and 92% in mucinous cystadenocarcinoma, respectively. LSD1 expression levels were associated with International Federation of Gynecology and Obstetrics stage and lymphatic metastasis in both serous and mucinous cystadenocarcinoma samples. Kaplan-Meier curves suggested that overall survival time of patients with high LSD1 expression was significantly shorter than that of patients with low LSD1 expression. Multivariate Cox proportional hazard regression indicated that higher LSD1 expression was a significant independent predictor of poor survival of EOC patients (P = 0.016). CONCLUSIONS: These results suggest that LSD1 may be involved in carcinogenesis and progression with promising therapeutic potential for epithelial ovarian cancer. BioMed Central 2015-05-09 /pmc/articles/PMC4429353/ /pubmed/25956476 http://dx.doi.org/10.1186/s13048-015-0155-1 Text en © Chen et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Cong
Ge, Jing
Lu, Qibin
Ping, Guoqiang
Yang, Chunqing
Fang, Xuefeng
Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title_full Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title_fullStr Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title_full_unstemmed Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title_short Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
title_sort expression of lysine-specific demethylase 1 in human epithelial ovarian cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429353/
https://www.ncbi.nlm.nih.gov/pubmed/25956476
http://dx.doi.org/10.1186/s13048-015-0155-1
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