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Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

BACKGROUND: Optineurin is a gene associated with normal tension glaucoma and amyotrophic lateral sclerosis. It has been reported previously that in cultured RGC5 cells, the turnover of endogenous optineurin involves mainly the ubiquitin-proteasome pathway (UPP). When optineurin is upregulated or mut...

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Detalles Bibliográficos
Autores principales:	Ying, Hongyu, Turturro, Sanja, Nguyen, Tara, Shen, Xiang, Zelkha, Ruth, Johnson, Elaine C, Morrison, John C, Yue, Beatrice YJT
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429416/ https://www.ncbi.nlm.nih.gov/pubmed/25943884 http://dx.doi.org/10.1186/s12860-015-0060-x

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