A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulati...

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Autores principales: Mulrane, Laoighse, Gallagher, William M, O’Connor, Darran P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429417/
https://www.ncbi.nlm.nih.gov/pubmed/25927669
http://dx.doi.org/10.1186/s13058-014-0467-x
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author Mulrane, Laoighse
Gallagher, William M
O’Connor, Darran P
author_facet Mulrane, Laoighse
Gallagher, William M
O’Connor, Darran P
author_sort Mulrane, Laoighse
collection PubMed
description miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-014-0467-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-44294172015-05-14 A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer Mulrane, Laoighse Gallagher, William M O’Connor, Darran P Breast Cancer Res Viewpoint miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-014-0467-x) contains supplementary material, which is available to authorized users. BioMed Central 2014-11-18 2014 /pmc/articles/PMC4429417/ /pubmed/25927669 http://dx.doi.org/10.1186/s13058-014-0467-x Text en © Mulrane et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 6 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Mulrane, Laoighse
Gallagher, William M
O’Connor, Darran P
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title_full A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title_fullStr A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title_full_unstemmed A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title_short A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
title_sort novel mechanism of regulation of the anti-metastatic mir-31 by emsy in breast cancer
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429417/
https://www.ncbi.nlm.nih.gov/pubmed/25927669
http://dx.doi.org/10.1186/s13058-014-0467-x
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