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Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms

REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently le...

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Autores principales: Teixeira, Manoel Jacobsen, da Paz, Matheus Gomes da S, Bina, Mauro Tupiniquim, Santos, Scheila Nogueira, Raicher, Irina, Galhardoni, Ricardo, Fernandes, Diego Toledo, Yeng, Lin T, Baptista, Abrahão F, de Andrade, Daniel Ciampi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429458/
https://www.ncbi.nlm.nih.gov/pubmed/25935556
http://dx.doi.org/10.1186/s12883-015-0329-x
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author Teixeira, Manoel Jacobsen
da Paz, Matheus Gomes da S
Bina, Mauro Tupiniquim
Santos, Scheila Nogueira
Raicher, Irina
Galhardoni, Ricardo
Fernandes, Diego Toledo
Yeng, Lin T
Baptista, Abrahão F
de Andrade, Daniel Ciampi
author_facet Teixeira, Manoel Jacobsen
da Paz, Matheus Gomes da S
Bina, Mauro Tupiniquim
Santos, Scheila Nogueira
Raicher, Irina
Galhardoni, Ricardo
Fernandes, Diego Toledo
Yeng, Lin T
Baptista, Abrahão F
de Andrade, Daniel Ciampi
author_sort Teixeira, Manoel Jacobsen
collection PubMed
description REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently leaving the condition refractory to treatment with the standard methods used to manage neuropathic pain. Unfortunately, little is known about the pathophysiology of brachial plexus avulsion. Available evidence indicates that besides primary nerve root injury, central lesions related to the abrupt disconnection of nerve roots from the spinal cord may play an important role in the genesis of neuropathic pain in these patients and may explain in part its refractoriness to treatment. CONCLUSIONS: The understanding of both central and peripheral mechanisms that contribute to the development of pain is of major importance in order to propose more effective treatments for brachial plexus avulsion-related pain. This review focuses on the current understanding about the occurrence of neuropathic pain in these patients and the role played by peripheral and central mechanisms that provides insights into its treatment. SUMMARY: Pain after brachial plexus avulsion involves both peripheral and central components; thereby it is characterized as a mixed (central and peripheral) neuropathic pain syndrome.
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spelling pubmed-44294582015-05-14 Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms Teixeira, Manoel Jacobsen da Paz, Matheus Gomes da S Bina, Mauro Tupiniquim Santos, Scheila Nogueira Raicher, Irina Galhardoni, Ricardo Fernandes, Diego Toledo Yeng, Lin T Baptista, Abrahão F de Andrade, Daniel Ciampi BMC Neurol Review REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently leaving the condition refractory to treatment with the standard methods used to manage neuropathic pain. Unfortunately, little is known about the pathophysiology of brachial plexus avulsion. Available evidence indicates that besides primary nerve root injury, central lesions related to the abrupt disconnection of nerve roots from the spinal cord may play an important role in the genesis of neuropathic pain in these patients and may explain in part its refractoriness to treatment. CONCLUSIONS: The understanding of both central and peripheral mechanisms that contribute to the development of pain is of major importance in order to propose more effective treatments for brachial plexus avulsion-related pain. This review focuses on the current understanding about the occurrence of neuropathic pain in these patients and the role played by peripheral and central mechanisms that provides insights into its treatment. SUMMARY: Pain after brachial plexus avulsion involves both peripheral and central components; thereby it is characterized as a mixed (central and peripheral) neuropathic pain syndrome. BioMed Central 2015-05-04 /pmc/articles/PMC4429458/ /pubmed/25935556 http://dx.doi.org/10.1186/s12883-015-0329-x Text en © Teixeira et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Teixeira, Manoel Jacobsen
da Paz, Matheus Gomes da S
Bina, Mauro Tupiniquim
Santos, Scheila Nogueira
Raicher, Irina
Galhardoni, Ricardo
Fernandes, Diego Toledo
Yeng, Lin T
Baptista, Abrahão F
de Andrade, Daniel Ciampi
Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title_full Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title_fullStr Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title_full_unstemmed Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title_short Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
title_sort neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429458/
https://www.ncbi.nlm.nih.gov/pubmed/25935556
http://dx.doi.org/10.1186/s12883-015-0329-x
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