Cargando…
Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms
REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently le...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429458/ https://www.ncbi.nlm.nih.gov/pubmed/25935556 http://dx.doi.org/10.1186/s12883-015-0329-x |
_version_ | 1782371038033608704 |
---|---|
author | Teixeira, Manoel Jacobsen da Paz, Matheus Gomes da S Bina, Mauro Tupiniquim Santos, Scheila Nogueira Raicher, Irina Galhardoni, Ricardo Fernandes, Diego Toledo Yeng, Lin T Baptista, Abrahão F de Andrade, Daniel Ciampi |
author_facet | Teixeira, Manoel Jacobsen da Paz, Matheus Gomes da S Bina, Mauro Tupiniquim Santos, Scheila Nogueira Raicher, Irina Galhardoni, Ricardo Fernandes, Diego Toledo Yeng, Lin T Baptista, Abrahão F de Andrade, Daniel Ciampi |
author_sort | Teixeira, Manoel Jacobsen |
collection | PubMed |
description | REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently leaving the condition refractory to treatment with the standard methods used to manage neuropathic pain. Unfortunately, little is known about the pathophysiology of brachial plexus avulsion. Available evidence indicates that besides primary nerve root injury, central lesions related to the abrupt disconnection of nerve roots from the spinal cord may play an important role in the genesis of neuropathic pain in these patients and may explain in part its refractoriness to treatment. CONCLUSIONS: The understanding of both central and peripheral mechanisms that contribute to the development of pain is of major importance in order to propose more effective treatments for brachial plexus avulsion-related pain. This review focuses on the current understanding about the occurrence of neuropathic pain in these patients and the role played by peripheral and central mechanisms that provides insights into its treatment. SUMMARY: Pain after brachial plexus avulsion involves both peripheral and central components; thereby it is characterized as a mixed (central and peripheral) neuropathic pain syndrome. |
format | Online Article Text |
id | pubmed-4429458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44294582015-05-14 Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms Teixeira, Manoel Jacobsen da Paz, Matheus Gomes da S Bina, Mauro Tupiniquim Santos, Scheila Nogueira Raicher, Irina Galhardoni, Ricardo Fernandes, Diego Toledo Yeng, Lin T Baptista, Abrahão F de Andrade, Daniel Ciampi BMC Neurol Review REVIEW: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently leaving the condition refractory to treatment with the standard methods used to manage neuropathic pain. Unfortunately, little is known about the pathophysiology of brachial plexus avulsion. Available evidence indicates that besides primary nerve root injury, central lesions related to the abrupt disconnection of nerve roots from the spinal cord may play an important role in the genesis of neuropathic pain in these patients and may explain in part its refractoriness to treatment. CONCLUSIONS: The understanding of both central and peripheral mechanisms that contribute to the development of pain is of major importance in order to propose more effective treatments for brachial plexus avulsion-related pain. This review focuses on the current understanding about the occurrence of neuropathic pain in these patients and the role played by peripheral and central mechanisms that provides insights into its treatment. SUMMARY: Pain after brachial plexus avulsion involves both peripheral and central components; thereby it is characterized as a mixed (central and peripheral) neuropathic pain syndrome. BioMed Central 2015-05-04 /pmc/articles/PMC4429458/ /pubmed/25935556 http://dx.doi.org/10.1186/s12883-015-0329-x Text en © Teixeira et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Teixeira, Manoel Jacobsen da Paz, Matheus Gomes da S Bina, Mauro Tupiniquim Santos, Scheila Nogueira Raicher, Irina Galhardoni, Ricardo Fernandes, Diego Toledo Yeng, Lin T Baptista, Abrahão F de Andrade, Daniel Ciampi Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title_full | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title_fullStr | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title_full_unstemmed | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title_short | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
title_sort | neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429458/ https://www.ncbi.nlm.nih.gov/pubmed/25935556 http://dx.doi.org/10.1186/s12883-015-0329-x |
work_keys_str_mv | AT teixeiramanoeljacobsen neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT dapazmatheusgomesdas neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT binamaurotupiniquim neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT santosscheilanogueira neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT raicheririna neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT galhardoniricardo neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT fernandesdiegotoledo neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT yenglint neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT baptistaabrahaof neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms AT deandradedanielciampi neuropathicpainafterbrachialplexusavulsioncentralandperipheralmechanisms |