HCV Kinetic Models and Their Implications in Drug Development

Chronic infection with hepatitis C virus (HCV) affects about 170 million people worldwide and is a major cause of liver complications. Mathematical modeling of viral kinetics under treatment has provided insight into the viral life cycle, treatment effectiveness, and drugs' mechanisms of action...

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Detalles Bibliográficos
Autores principales: Nguyen, THT, Guedj, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429577/
https://www.ncbi.nlm.nih.gov/pubmed/26225247
http://dx.doi.org/10.1002/psp4.28
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author Nguyen, THT
Guedj, J
author_facet Nguyen, THT
Guedj, J
author_sort Nguyen, THT
collection PubMed
description Chronic infection with hepatitis C virus (HCV) affects about 170 million people worldwide and is a major cause of liver complications. Mathematical modeling of viral kinetics under treatment has provided insight into the viral life cycle, treatment effectiveness, and drugs' mechanisms of action. Here we review the implications of viral kinetic models at the different stages of development of anti-HCV agents.
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spelling pubmed-44295772015-05-13 HCV Kinetic Models and Their Implications in Drug Development Nguyen, THT Guedj, J CPT Pharmacometrics Syst Pharmacol Review Chronic infection with hepatitis C virus (HCV) affects about 170 million people worldwide and is a major cause of liver complications. Mathematical modeling of viral kinetics under treatment has provided insight into the viral life cycle, treatment effectiveness, and drugs' mechanisms of action. Here we review the implications of viral kinetic models at the different stages of development of anti-HCV agents. BlackWell Publishing Ltd 2015-04 2015-04-17 /pmc/articles/PMC4429577/ /pubmed/26225247 http://dx.doi.org/10.1002/psp4.28 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Nguyen, THT
Guedj, J
HCV Kinetic Models and Their Implications in Drug Development
title HCV Kinetic Models and Their Implications in Drug Development
title_full HCV Kinetic Models and Their Implications in Drug Development
title_fullStr HCV Kinetic Models and Their Implications in Drug Development
title_full_unstemmed HCV Kinetic Models and Their Implications in Drug Development
title_short HCV Kinetic Models and Their Implications in Drug Development
title_sort hcv kinetic models and their implications in drug development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429577/
https://www.ncbi.nlm.nih.gov/pubmed/26225247
http://dx.doi.org/10.1002/psp4.28
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